口咽鳞状细胞癌咽后淋巴结转移的流行率和预后影响：文献荟萃分析。

Prevalence and prognostic impact of retropharyngeal lymph nodes metastases in oropharyngeal squamous cell carcinoma: Meta-analysis of published literature.

机构信息

Department of Medical, Surgical, and Health Sciences, Section of Otolaryngology, University of Trieste, Trieste, Italy.

Department of ENT, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

出版信息

Head Neck. 2022 Oct;44(10):2265-2276. doi: 10.1002/hed.27166. Epub 2022 Aug 1.

BACKGROUND

This systematic review and meta-analysis aims to estimate the prevalence and prognostic impact of retropharyngeal lymph node metastases (RLNMs) in oropharyngeal squamous cell carcinoma (OPSCC).

METHODS

This meta-analysis was conducted according to PRISMA guidelines.

INCLUSION CRITERIA

studies with more than 20 patients reporting the prevalence or prognostic impact of RLNMs in OPSCC. Whenever available, data on HPV status and subsites were extracted.

RESULTS

Twenty-two articles were included. The overall prevalence of RLNMs in OPSCC was 13%, with no significant differences depending on HPV status. The highest prevalence was observed for posterior pharyngeal wall SCC (24%), followed by soft palate (17%), palatine tonsil (15%), and base of tongue (8%). RLNMs were associated with a significantly higher risk of death (HR:2.54;IC95%1.89-3.41) and progression (HR:2.44;IC95%1.80-3.30).

CONCLUSIONS

The prevalence of RLNMs in OPSCC was 13%, being higher in tumors of the posterior pharyngeal wall. RLNMs were associated with unfavorable outcomes.

背景

本系统评价和荟萃分析旨在评估口咽鳞状细胞癌（OPSCC）中咽后淋巴结转移（RLNM）的发生率和预后影响。

方法

本荟萃分析按照 PRISMA 指南进行。

纳入标准

报道 OPSCC 中 RLNM 发生率或预后影响的超过 20 例患者的研究。只要有数据，就提取 HPV 状态和亚部位的数据。

结果

共纳入 22 篇文章。OPSCC 中 RLNM 的总体发生率为 13%，与 HPV 状态无关。后咽壁 SCC 的发生率最高（24%），其次是软腭（17%）、腭扁桃体（15%）和舌根（8%）。RLNM 与死亡风险显著增加相关（HR：2.54；95%CI1.89-3.41）和进展（HR：2.44；95%CI1.80-3.30）。