Nicolson G L, Brunson K W, Fidler I J
Cancer Res. 1978 Nov;38(11 Pt 2):4105-11.
Animal tumor models for blood-borne metastasis have been developed by in vitro cloning or in vivo selection of malignant tumor cell populations to obtain organ-preferring variant tumor cell lines with altered arrest, survival, invasion, and growth properties. Selection and some tumor cell characteristics of lung-, brain-, and ovary-colonizing metastatic B16 melanoma, liver-colonizing RAW114 lymphosarcoma, and lung-colonizing MSV3T3 vasoformative sarcoma variant lines will be discussed along with additional data, suggesting that tumor cells of varying malignant potential preeexist in the unselected tumor population.
通过体外克隆或体内选择恶性肿瘤细胞群体，已建立了用于血行转移的动物肿瘤模型，以获得具有改变的滞留、存活、侵袭和生长特性的器官偏好性变异肿瘤细胞系。本文将讨论肺、脑和卵巢定植的转移性B16黑色素瘤、肝定植的RAW114淋巴肉瘤以及肺定植的MSV3T3血管形成性肉瘤变异株系的选择和一些肿瘤细胞特征，并提供更多数据，表明不同恶性潜能的肿瘤细胞在未选择的肿瘤群体中预先存在。
