Comber中的一种新的C-二萜生物碱。

A new C-diterpenoid alkaloid in Comber.

作者信息

Yao Lin-Lin, Zhang Sheng-Qi, Guo Ce, Li Bin-Xian, Yang Hua-Juan, Yin Tian-Peng, Cai Le

机构信息

School of Chemical Science and Engineering, Yunnan University, Kunming, P.R. China.

Faculty of Bioengineering, Zhuhai Campus of Zunyi Medical University, Guangdong, P.R. China.

出版信息

Nat Prod Res. 2024 Jan-Feb;38(1):85-90. doi: 10.1080/14786419.2022.2104276. Epub 2022 Aug 1.

DOI:10.1080/14786419.2022.2104276

PMID:35913407

Abstract

Nine diterpenoid alkaloids were isolated from Comber belonging to the genus in Ranunculaceae family. Their structures were determinated by using HR-ESI-MS and 1 D/2D NMR spectra as geordine (), yunaconitine (), chasmanine (), crassicauline A (), forestine (), pseudaconine (), 14-acetylalatisamine (), austroconitine B (), and talatisamine (). Among them, compound is a previously undescribed aconitine-type C-diterpenoid alkaloid, and compounds , and - have not previously been isolated from this species. The results of experiments indicated that new compound possesses mild anti-inflammatory activity, which inhibited the production of NO in LPS-activated RAW 264.7 cells with an inhibition ratio of 29.75% at 50 μM.

摘要

从毛茛科翠雀属植物中分离得到9个二萜生物碱。通过高分辨电喷雾电离质谱（HR-ESI-MS）和一维/二维核磁共振谱（1D/2D NMR）确定了它们的结构，分别为吉尔多因（）、云乌头碱（）、查斯曼宁（）、粗茎乌甲素A（）、福林碱（）、伪乌头碱（）、14-乙酰阿拉他明（）、澳洲乌头碱B（）和塔拉胺（）。其中，化合物为一种前所未有的乌头碱型C-二萜生物碱，化合物、和此前未从该物种中分离得到。实验结果表明，新化合物具有温和的抗炎活性，在50μM浓度下对脂多糖（LPS）激活的RAW 264.7细胞中一氧化氮（NO）的产生具有抑制作用，抑制率为29.75%。