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通过温和的硼化环化串联反应合成硼氮-多芳烃

Synthesis of BN-Polyarenes by a Mild Borylative Cyclization Cascade.

作者信息

Sans-Panadés Ester, Vaquero Juan J, Fernández-Rodríguez Manuel A, García-García Patricia

机构信息

Universidad de Alcalá (IRYCIS). Departamento de Química Orgánica y Química Inorgánica, Instituto de Investigación Química "Andrés M. del Río" (IQAR). Campus Científico-Tecnológico, Facultad de Farmacia. Autovía A-II, Km 33.1, 28805-Alcalá de Henares, Madrid, Spain.

出版信息

Org Lett. 2022 Aug 12;24(31):5860-5865. doi: 10.1021/acs.orglett.2c02477. Epub 2022 Aug 1.

DOI:10.1021/acs.orglett.2c02477
PMID:35913827
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9384698/
Abstract

Reaction of BCl with suitably substituted -alkynylanilines promotes a cascade reaction in which BN-polycyclic compounds are obtained via the formation of two new cycles and three new bonds in a single operational step. The reaction is highly efficient and takes place at room temperature, providing a very mild and straightforward strategy for the preparation of BN-aromatic compounds, which can be further transformed into a variety of BN-PAHs with different polycyclic cores and substituents.

摘要

BCl与适当取代的炔基苯胺反应会引发级联反应，通过在单个操作步骤中形成两个新环和三个新键来获得BN多环化合物。该反应效率很高，在室温下即可发生，为制备BN芳香族化合物提供了一种非常温和且直接的策略，这些化合物可进一步转化为具有不同多环核心和取代基的各种BN-PAHs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/edccbaf714ed/ol2c02477_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/2e6a6f532f2c/ol2c02477_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/f362607cb73b/ol2c02477_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/7baee0f407d0/ol2c02477_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/c3d9be54c73a/ol2c02477_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/efba5ecbbe31/ol2c02477_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/d8c0d65f8ef6/ol2c02477_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/edccbaf714ed/ol2c02477_0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/2e6a6f532f2c/ol2c02477_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/f362607cb73b/ol2c02477_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/7baee0f407d0/ol2c02477_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/c3d9be54c73a/ol2c02477_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/efba5ecbbe31/ol2c02477_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/d8c0d65f8ef6/ol2c02477_0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e094/9384698/edccbaf714ed/ol2c02477_0007.jpg

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