Department of Urology, First Affiliated Hospital of Nanjing Medical University, No. 300, Guangzhou Street, Nanjing, Jiangsu Province 210029, China.
The First Clinical School of Nanjing Medical University, Nanjing, Jiangsu Province 210029, China.
Ecotoxicol Environ Saf. 2022 Sep 1;242:113930. doi: 10.1016/j.ecoenv.2022.113930. Epub 2022 Jul 30.
This study aimed to investigate the relationship between phthalate metabolites and renal function.
We analyzed data from 9989 participants who took part in the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. Renal function was reflected by estimated glomerular filtration rate (eGFR), urinary albumin-to-creatinine ratio (UACR), and hypertension. We used generalized linear regression to estimate the correlation between covariate-adjusted creatinine-normalized phthalate metabolites and renal function. In addition, subgroup analysis was used to further compare the effect differences between various populations.
In the adjusted model, we found differential associations between phthalates and plasticizers metabolites and renal function. We found that Mono-benzyl phthalate, Mono-(3-carboxypropyl) phthalate, and Mono-(2-ethyl-5-oxohexyl) phthalate were positively associated with lower eGFR with odds ratios (95% confidence intervals) of 1.38 (1.14, 1.67), 1.30 (1.09, 1.57), and 1.27 (1.04, 1.53). While Mono-ethyl phthalate, Mono-(2-ethyl)-hexyl phthalate, Mono-isononyl phthalate and Mono-isobutyl phthalate were negatively associated with lower eGFR with OR values of 0.79 (0.69, 0.90), 0.64 (0.52, 0.78), 0.65 (0.51, 0.82) and 0.80 (0.63, 1.00), respectively. In addition, we found that Mono(carboxyoctyl) phthalate and Mono-isobutyl phthalate were negatively associated with hypertension with ORs of 0.86 (0.78, 0.96) and 0.84 (0.72, 0.98). But phthalates and plasticizers metabolites were not associated with UACR.
This study found differences in the effects of phthalates and plasticizers metabolites on kidney function, which may raise concerns about possible changes in kidney function resulting from exposure to current levels of plasticizers.
本研究旨在探讨邻苯二甲酸酯代谢物与肾功能之间的关系。
我们分析了 2005 年至 2018 年参加国家健康和营养调查（NHANES）的 9989 名参与者的数据。肾功能通过估算肾小球滤过率（eGFR）、尿白蛋白与肌酐比值（UACR）和高血压来反映。我们使用广义线性回归来估计调整协变量后的肌酐归一化邻苯二甲酸酯代谢物与肾功能之间的相关性。此外，还进行了亚组分析，以进一步比较不同人群之间的效果差异。
在调整模型中，我们发现邻苯二甲酸酯和增塑剂代谢物与肾功能之间存在差异关联。我们发现，单苄基邻苯二甲酸酯、单-(3-羧丙基)邻苯二甲酸酯和单-(2-乙基-5-氧代己基)邻苯二甲酸酯与较低的 eGFR 呈正相关，优势比（95%置信区间）分别为 1.38（1.14，1.67）、1.30（1.09，1.57）和 1.27（1.04，1.53）。而单乙基邻苯二甲酸酯、单-(2-乙基己基)邻苯二甲酸酯、单-异壬基邻苯二甲酸酯和单-异丁基邻苯二甲酸酯与较低的 eGFR 呈负相关，优势比（OR）值分别为 0.79（0.69，0.90）、0.64（0.52，0.78）、0.65（0.51，0.82）和 0.80（0.63，1.00）。此外，我们发现单（羧辛基）邻苯二甲酸酯和单异丁基邻苯二甲酸酯与高血压呈负相关，优势比（OR）分别为 0.86（0.78，0.96）和 0.84（0.72，0.98）。但是，邻苯二甲酸酯和增塑剂代谢物与 UACR 无关。
本研究发现邻苯二甲酸酯和增塑剂代谢物对肾功能的影响存在差异，这可能引起人们对当前水平的增塑剂暴露可能导致肾功能变化的关注。
