Wang Hao, Cui Yixin, Zhang Fan, Song Ruihan, Zhao Longzhu, Han Miaomiao, Shen Xiaoli
Department of Epidemiology and Health Statistics, Medical College of Qingdao University, No. 308 Ningxia Rd, Qingdao, 266071, China.
Environ Sci Pollut Res Int. 2023 Mar;30(14):41445-41459. doi: 10.1007/s11356-022-25051-9. Epub 2023 Jan 12.
Phthalate metabolites have been detected from urine in most of the US population and have become a public health problem. However, the association between phthalate metabolites and hyperuricemia has been scarcely studied so far. We aimed to evaluate if phthalate metabolites were associated with hyperuricemia in US adults. A total of 8816 participants of the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 were included in our study. We used multivariable logistic regression models and restricted cubic spline (RCS) models to explore the association between urinary phthalate metabolites and hyperuricemia. Then, stratified analyses were conducted by sex and age. The prevalence of hyperuricemia in the study sample was 20.35%. Compared to the lowest quantile, the odds ratios (ORs) and 95% confidence intervals (CIs) for hyperuricemia were all statistically significant in following phthalate metabolites: 1.34 (1.13-1.58) for the second quartile in Mono-isobutyl phthalate (MiBP), 1.21 (1.01-1.46) for the highest quartile in Mono-(carboxyoctyl) phthalate (MCOP), 0.66 (0.56-0.76) for the second quartile in Mono-(2-ethyl)-hexyl phthalate (MEHP), 1.22 (1.05-1.43) for quartile 2 in Benzyl butyl phthalate (ΣBBP), and 1.43 (1.22-1.66) for the third quartile in high molecular-weight phthalate (ΣHigh MWP), respectively. Our results indicate that several urinary phthalate metabolites are positively associated with the odds of hyperuricemia.
在美国大部分人群的尿液中都检测到了邻苯二甲酸酯代谢物，这已成为一个公共卫生问题。然而，到目前为止，邻苯二甲酸酯代谢物与高尿酸血症之间的关联鲜有研究。我们旨在评估在美国成年人中邻苯二甲酸酯代谢物是否与高尿酸血症有关。我们的研究纳入了2005年至2018年美国国家健康与营养检查调查（NHANES）的8816名参与者。我们使用多变量逻辑回归模型和受限立方样条（RCS）模型来探究尿邻苯二甲酸酯代谢物与高尿酸血症之间的关联。然后，按性别和年龄进行分层分析。研究样本中高尿酸血症的患病率为20.35%。与最低四分位数相比，以下邻苯二甲酸酯代谢物中高尿酸血症的比值比（OR）和95%置信区间（CI）均具有统计学意义：邻苯二甲酸单异丁酯（MiBP）第二四分位数为1.34（1.13 - 1.58），邻苯二甲酸单（羧基辛基）酯（MCOP）最高四分位数为1.21（1.01 - 1.46），邻苯二甲酸单（2 - 乙基）己酯（MEHP）第二四分位数为0.66（0.56 - 0.76），邻苯二甲酸苄基丁酯（ΣBBP）四分位数2为1.22（1.05 - 1.43），高分子量邻苯二甲酸酯（ΣHigh MWP）第三四分位数为1.43（1.22 - 1.66）。我们的结果表明，几种尿邻苯二甲酸酯代谢物与高尿酸血症的发生几率呈正相关。
