Department of Orthopaedics, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
School of Public Health, Hangzhou Medical College, Hangzhou, China.
Ecotoxicol Environ Saf. 2021 Feb;209:111787. doi: 10.1016/j.ecoenv.2020.111787. Epub 2020 Dec 14.
The potential association of exposure to phthalates with muscle strength was reported in previous animal experiments. However, their association was rarely directly investigated in general populations. Thus, we aimed to ascertain the association of exposure to phthalates with grip strength using cross-sectional analysis which included 2436 individuals aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) during 2011-2014. The multivariable linear regression models were performed with the adjustment of related covariates. The results suggested that a one-unit increase in log-transformed phthalate metabolites (μg/g creatinine) was inversely associated with grip strength, including Mono-(2-ethyl)-hexyl phthalate (β: -2.727 kg, 95% CI: -3.452, -2.002), Mono-(2-ethyl-5-hydroxyhexyl) phthalate (β: -3.721 kg, 95% CI: -4.836, -2.607), Mono-(2-ethyl-5-oxohexl) phthalate (β: -4.669 kg, 95% CI: -5.761, -3.577), Mono-2-ethyl-5-carboxypentyl phthalate (β: -4.756 kg, 95% CI: -5.957, -3.554), Mono-carboxyoctyl phthalate (β: -1.324 kg, 95% CI: -2.412, -0.235), Mono-carboxynonyl phthalate (β: -2.036 kg, 95% CI: -3.185, -0.886), Mono-benzyl phthalate (β: -2.940 kg, 95% CI: -3.853, -2.026), Mono-n-butyl phthalate (β: -2.100 kg, 95% CI: -3.474, -0.726), Mono-isobutyl phthalate (β: -2.982 kg, 95% CI: -4.331, -1.633), and Mono-ethyl phthalate (β: -1.709 kg, 95% CI: -2.368, -1.050). In subgroup analyses, the associations remained largely unchanged when the samples were stratified by gender and age; However they became ambiguous among underweight subjects when the samples were stratified by BMI status. Overall, exposure to phthalates was inversely associated with grip strength among US adults, regardless of their genders and ages. The suggestive potential BMI status-specific effects of phthalates on grip strength were observed.
先前的动物实验报告了邻苯二甲酸酯暴露与肌肉力量之间存在潜在关联。然而，在一般人群中，很少有直接研究它们之间关联的。因此，我们旨在通过横断面分析来确定邻苯二甲酸酯暴露与握力之间的关联，该分析包括了 2011-2014 年期间国家健康和营养检查调查（NHANES）中 2436 名年龄≥20 岁的个体。使用多变量线性回归模型，并对相关协变量进行了调整。结果表明，邻苯二甲酸酯代谢物（μg/g 肌酐）的对数每增加一个单位，与握力呈负相关，包括单（2-乙基）己基邻苯二甲酸酯（β：-2.727 kg，95%CI：-3.452，-2.002）、单（2-乙基-5-羟基己基）邻苯二甲酸酯（β：-3.721 kg，95%CI：-4.836，-2.607）、单（2-乙基-5-氧代己基）邻苯二甲酸酯（β：-4.669 kg，95%CI：-5.761，-3.577）、单-2-乙基-5-羧基戊基邻苯二甲酸酯（β：-4.756 kg，95%CI：-5.957，-3.554）、单-羧基辛基邻苯二甲酸酯（β：-1.324 kg，95%CI：-2.412，-0.235）、单-羧基壬基邻苯二甲酸酯（β：-2.036 kg，95%CI：-3.185，-0.886）、单-苄基邻苯二甲酸酯（β：-2.940 kg，95%CI：-3.853，-2.026）、单-正丁基邻苯二甲酸酯（β：-2.100 kg，95%CI：-3.474，-0.726）、单-异丁基邻苯二甲酸酯（β：-2.982 kg，95%CI：-4.331，-1.633）和单-乙基邻苯二甲酸酯（β：-1.709 kg，95%CI：-2.368，-1.050）。在亚组分析中，当按性别和年龄对样本进行分层时，这些关联基本保持不变；然而，当按 BMI 状态对样本进行分层时，在体重不足的受试者中，这些关联变得不明确。总体而言，无论其性别和年龄如何，美国成年人邻苯二甲酸酯暴露与握力呈负相关。观察到邻苯二甲酸酯对握力的潜在 BMI 状态特异性影响。
