从多囊卵巢综合征患者中生成诱导多能干细胞系 AMUFAHi002-A。
Generation of an induced pluripotent stem cell line AMUFAHi002-A from polycystic ovary syndrome patient.
机构信息
Reproductive Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China.
Reproductive Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Anhui Medical University, No 218 Jixi Road, Hefei 230022, Anhui, China; Anhui Province Key Laboratory of Reproductive Health and Genetics, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University), No 81 Meishan Road, Hefei 230032, Anhui, China.
出版信息
Stem Cell Res. 2022 Aug;63:102875. doi: 10.1016/j.scr.2022.102875. Epub 2022 Jul 28.
Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine disorders in women of reproductive age. The PCOS leads to obesity, dyslipidemia, insulin resistance, hyperandrogenism, and infertility. We established an induced pluripotent stem cell line (iPSC) from a PCOS patient. This disease-specific iPSC line will be beneficial to study PCOS in vitro, allowing to understand the pathogenic mechanisms and a cell-based model for drug development for PCOS.
多囊卵巢综合征（PCOS）是生育期妇女最常见的内分泌疾病之一。PCOS 可导致肥胖、血脂异常、胰岛素抵抗、高雄激素血症和不孕。我们从 PCOS 患者中建立了诱导多能干细胞系（iPSC）。这种疾病特异性的 iPSC 系将有利于 PCOS 的体外研究，有助于了解发病机制和 PCOS 的药物开发的基于细胞的模型。
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