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COVID-19 大流行对髋部骨折患者医院死亡率的间接影响:使用链接行政数据的竞争风险生存分析。

Indirect effect of the COVID-19 pandemic on hospital mortality in patients with hip fracture: a competing risk survival analysis using linked administrative data.

机构信息

The Health Foundation, London, UK

University Hospital of Wales and Cardiff University School of Medicine, Cardiff, UK.

出版信息

BMJ Qual Saf. 2023 May;32(5):264-273. doi: 10.1136/bmjqs-2022-014896. Epub 2022 Aug 1.


DOI:10.1136/bmjqs-2022-014896
PMID:35914925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10176403/
Abstract

BACKGROUND: Hip fracture is a leading cause of disability and mortality among older people. During the COVID-19 pandemic, orthopaedic care pathways in the National Health Service in England were restructured to manage pressures on hospital capacity. We examined the indirect consequences of the pandemic for hospital mortality among older patients with hip fracture, admitted from care homes or the community. METHODS: Retrospective analysis of linked care home and hospital inpatient data for patients with hip fracture aged 65 years and over admitted to hospitals in England during the first year of the pandemic (1 March 2020 to 28 February 2021) or during the previous year. We performed survival analysis, adjusting for case mix and COVID-19 infection, and considered live discharge as a competing risk. We present cause-specific hazard ratios (HR) for the effect of admission year on hospital mortality risk. RESULTS: During the first year of the pandemic, there were 55 648 hip fracture admissions: a 5.2% decrease on the previous year. 9.5% of patients had confirmed or suspected COVID-19. Hospital stays were substantially shorter (p<0.05), and there was a higher daily chance of discharge (HR 1.40, 95% CI 1.38 to 1.41). Overall hip fracture inpatient mortality increased (7.2% in 2020/2021 vs 6.4% in 2019/2020), but patients without concomitant COVID-19 infection had lower mortality rates compared with the year before (5.3%). Admission during the pandemic was associated with a 11% increase in the daily risk of hospital death for patients with hip fracture (HR 1.11, 95% CI 1.05 to 1.16). CONCLUSIONS: Although COVID-19 infections led to increases in hospital mortality, overall hospital mortality risk for older patients with hip fracture remained largely stable during the first year of the pandemic.

摘要

背景:髋部骨折是老年人残疾和死亡的主要原因。在 COVID-19 大流行期间,英国国民保健制度中的骨科护理途径进行了重组,以应对医院容量的压力。我们研究了大流行对从养老院或社区入院的老年髋部骨折患者的医院死亡率的间接影响。

方法:对 2020 年 3 月 1 日至 2021 年 2 月 28 日期间或前一年期间在英格兰医院入院的 65 岁及以上髋部骨折患者的养老院和医院住院数据进行回顾性分析。我们进行了生存分析,调整了病例组合和 COVID-19 感染,并将存活出院视为竞争风险。我们报告了入院年份对医院死亡率风险的特定原因危害比(HR)。

结果:在大流行的第一年,有 55648 例髋部骨折入院:比前一年减少了 5.2%。9.5%的患者有确诊或疑似 COVID-19。住院时间明显缩短(p<0.05),每日出院的机会更高(HR 1.40,95%CI 1.38 至 1.41)。髋部骨折住院患者的总体死亡率上升(2020/2021 年为 7.2%,而 2019/2020 年为 6.4%),但无合并 COVID-19 感染的患者的死亡率低于前一年(5.3%)。大流行期间入院与髋部骨折患者每日住院死亡风险增加 11%相关(HR 1.11,95%CI 1.05 至 1.16)。

结论:尽管 COVID-19 感染导致医院死亡率上升,但在大流行的第一年,老年髋部骨折患者的总体医院死亡率风险基本保持稳定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/d2050816d102/bmjqs-2022-014896f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/a91ce11712dd/bmjqs-2022-014896f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/1a2a3609c6c7/bmjqs-2022-014896f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/d2050816d102/bmjqs-2022-014896f03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/a91ce11712dd/bmjqs-2022-014896f01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/1a2a3609c6c7/bmjqs-2022-014896f02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1d40/10176403/d2050816d102/bmjqs-2022-014896f03.jpg

相似文献

[1]
Indirect effect of the COVID-19 pandemic on hospital mortality in patients with hip fracture: a competing risk survival analysis using linked administrative data.

BMJ Qual Saf. 2023-5

[2]
Has a change in established care pathways during the first wave of the COVID-19 pandemic led to an excess death rate in the fragility fracture population? A longitudinal cohort study of 1846 patients.

BMJ Open. 2022-5-6

[3]
Increased Mortality and Major Complications in Hip Fracture Care During the COVID-19 Pandemic: A New York City Perspective.

J Orthop Trauma. 2020-8

[4]
IMPACT-Global Hip Fracture Audit: Nosocomial infection, risk prediction and prognostication, minimum reporting standards and global collaborative audit: Lessons from an international multicentre study of 7,090 patients conducted in 14 nations during the COVID-19 pandemic.

Surgeon. 2022-12

[5]
Hip Fracture Outcomes During the COVID-19 Pandemic: Early Results From New York.

J Orthop Trauma. 2020-8

[6]
IMPACT-Scot 2 report on COVID-19 in hip fracture patients.

Bone Joint J. 2021-5

[7]
Perioperative mortality and morbidity of hip fractures among COVID-19 infected and non-infected patients: A systematic review and meta-analysis.

Chin J Traumatol. 2023-5

[8]
Meta-analysis and metaregression of risk factors associated with mortality in hip fracture patients during the COVID-19 pandemic.

Sci Rep. 2021-5-12

[9]
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JAMA Netw Open. 2021-11-1

[10]
The effects of COVID-19 on perioperative morbidity and mortality in patients with hip fractures.

Bone Joint J. 2020-7-7

引用本文的文献

[1]
Trends in falls among older adults before and during the COVID-19 pandemic in Ontario, Canada: A retrospective observational study.

BMC Geriatr. 2024-5-11

[2]
Effects of the COVID-19 pandemic on secondary care for cardiovascular disease in the UK: an electronic health record analysis across three countries.

Eur Heart J Qual Care Clin Outcomes. 2023-6-21

本文引用的文献

[1]
A novel method for identifying care home residents in England: a validation study.

Int J Popul Data Sci. 2021-9-15

[2]
Differences in health care spending and utilization among older frail adults in high-income countries: ICCONIC hip fracture persona.

Health Serv Res. 2021-12

[3]
Differences in health outcomes for high-need high-cost patients across high-income countries.

Health Serv Res. 2021-12

[4]
Hospital admissions from care homes in England during the COVID-19 pandemic: a retrospective, cross-sectional analysis using linked administrative data.

Int J Popul Data Sci. 2021-7-8

[5]
Evolution and effects of COVID-19 outbreaks in care homes: a population analysis in 189 care homes in one geographical region of the UK.

Lancet Healthy Longev. 2020-10

[6]
A view of COVID-19 from the perspective of the National Hip Fracture Database.

Bone Joint J. 2021-6

[7]
Early mortality outcomes of patients with fragility hip fracture and concurrent SARS-CoV-2 infection : a systematic review and meta-analysis.

Bone Jt Open. 2021-5

[8]
Hip fracture characteristics and outcomes during COVID-19: a large retrospective national database review.

Br J Anaesth. 2021-7

[9]
Excess mortality for care home residents during the first 23 weeks of the COVID-19 pandemic in England: a national cohort study.

BMC Med. 2021-3-5

[10]
The impact of COVID-19 on the management and outcomes of patients with proximal femoral fractures: a multi-centre study of 580 patients.

J Orthop Surg Res. 2021-2-24

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