Gupta Preeti, Man Ryan Eyn Kidd, Fenwick Eva K, Qian Chaoxu, Sim Ralene, Majithia Shivani, Tham Yih Chung, Sabanayagam Charumathi, Wong Tien Yin, Cheng Ching-Yu, Lamoureux Ecosse Luc
Singapore Eye Research Institute, and Singapore National Eye Centre, Singapore.
Duke-NUS Medical School, Singapore.
Br J Ophthalmol. 2023 Nov;107(11):1590-1596. doi: 10.1136/bjo-2021-320873. Epub 2022 Aug 1.
Association between baseline visual impairment (VI) bilaterality and severity, and associated causes; and incident and frequent falls at 6 years in a multiethnic Asian population aged ≥60 years.
It is a population-based prospective cohort study. Visual acuity was clinically measured at both visits. Self-reported incidence and frequency of falls were defined as having no fall at baseline but having one fall and ≥2 incident falls in the 12 months prior to the follow-up visit, respectively.
Of the 1972 older participants (mean age (SD): 67.37 (5.4) years), 253 (12.8%) and 69 (3.5%) reported at least one fall and ≥2 falls, respectively, at a 6-year follow-up. After multivariable adjustments, baseline bilateral VI, but not unilateral, was associated with higher odds of any incident falls (mild bilateral VI: OR=1.79, 95% CI 1.07 to 2.98; moderate-severe VI in one eye and mild VI in the other eye: OR=1.58, 95% CI 1.01 to 2.47). However, having any form of bilateral VI (OR ranging between 2.46 and 4.32; all p<0.05) and even unilateral mild VI (OR=2.34, 95% CI 1.09 to 5.03) significantly increased the odds of incident frequent falls, compared with bilateral normal vision. VI caused by correctable (OR=2.02, 95% CI 1.19 to 3.44) and uncorrectable (OR=3.09, 95% CI 1.08 to 8.80) eye conditions were both associated with greater odds of incident frequent falls, compared with no VI.
Baseline bilateral but not unilateral VI conferred nearly two-fold higher odds of incident fall. Importantly, even mild unilateral VI conferred a substantially greater likelihood of frequent falls from correctable and uncorrectable conditions.
在年龄≥60岁的多民族亚洲人群中,基线双侧视力损害(VI)与严重程度、相关病因之间的关联;以及6年时的跌倒发生率和频繁跌倒情况。
这是一项基于人群的前瞻性队列研究。两次就诊时均进行了临床视力测量。自我报告的跌倒发生率和频率分别定义为基线时无跌倒但在随访就诊前12个月内有一次跌倒和≥2次跌倒。
在1972名老年参与者(平均年龄(标准差):67.37(5.4)岁)中,在6年随访时,分别有253人(12.8%)和69人(3.5%)报告至少有一次跌倒和≥2次跌倒。多变量调整后,基线双侧视力损害而非单侧视力损害与任何跌倒事件的较高几率相关(轻度双侧视力损害:比值比=1.79,95%置信区间1.07至2.98;一只眼中度至重度视力损害且另一只眼轻度视力损害:比值比=1.58,95%置信区间1.01至2.47)。然而,与双侧正常视力相比,任何形式的双侧视力损害(比值比在2.46至4.32之间;所有p<0.05)甚至单侧轻度视力损害(比值比=2.34,95%置信区间1.09至5.03)均显著增加了跌倒事件频繁发生的几率。与无视力损害相比,由可矫正(比值比=2.02,95%置信区间1.19至3.44)和不可矫正(比值比=3.09,95%置信区间1.08至8.80)眼部疾病引起的视力损害均与跌倒事件频繁发生的较高几率相关。
基线双侧而非单侧视力损害使跌倒事件的几率增加近两倍。重要的是,即使是轻度单侧视力损害,在可矫正和不可矫正情况下发生频繁跌倒的可能性也显著更高。