Rivlin R S
Adv Exp Med Biol. 1986;206:349-55. doi: 10.1007/978-1-4613-1835-4_26.
Riboflavin deficiency diminishes the rate of growth of spontaneous tumors in experimental animals but enhances the carcinogenicity of specific drugs such as the azo dyes, which are degraded by a microsomal hydroxylase system requiring riboflavin. Human esophageal cancer has been epidemiologically associated with riboflavin deficiency, but the precise role of riboflavin in this tumor remains to be defined. Riboflavin nutriture influences epithelial integrity, tissue flavin concentrations, rates of prostaglandin biosynthesis, and glutathione metabolism, each of which may have implications for carcinogenesis.
核黄素缺乏会降低实验动物自发肿瘤的生长速度，但会增强特定药物（如偶氮染料）的致癌性，这些偶氮染料可被需要核黄素的微粒体羟化酶系统降解。从流行病学角度来看，人类食管癌与核黄素缺乏有关，但核黄素在这种肿瘤中的确切作用仍有待确定。核黄素营养状况会影响上皮完整性、组织黄素浓度、前列腺素生物合成速率和谷胱甘肽代谢，其中每一项都可能与致癌作用有关。
