Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.
NanFang PET Center, Nanfang Hospital, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou, 510515, Guangdong, China.
BMC Gastroenterol. 2022 Aug 1;22(1):369. doi: 10.1186/s12876-022-02449-w.
To predict the histological grade and microvascular invasion (MVI) in patients with HCC.
A retrospective analysis was conducted on 175 patients who underwent MRI enhancement scanning (from September 2016.9 to October 2020). They were divided into MVI positive, MVI negative, Grade-high and Grade-low groups.
The AFP of 175 HCC patients distributed in MVI positive and negative groups, Grade-low and Grade-high groups were statistically significant (P = 0.002 and 0.03, respectively). Multiple HCC lesions were more common in MVI positive and Grade-high groups. Correspondingly, more single lesions were found in MVI negative and Grade-low groups (P = 0.005 and 0.019, respectively). Capsule on MRI was more common in MVI negative and Grade-high groups, and the difference was statistically significant (P = 0.02 and 0.011, respectively). There were statistical differences in the distribution of three MRI signs: artistic rim enhancement, artistic peripheral enhancement, and tumor margin between MVI positive and MVI negative groups (P = 0.001, < 0.001, and < 0.001, respectively). Tumor hypointensity on HBP was significantly different between MVI positive and negative groups (P < 0.001).
Our research shows that preoperative enhanced imaging can be used to predict MVI and tumor differentiation grade of HCC. The prognosis of MVI-negative group was better than that of MVI-positive group.
预测 HCC 患者的组织学分级和微血管侵犯（MVI）。
回顾性分析了 175 例接受 MRI 增强扫描的患者（2016 年 9 月至 2020 年 10 月）。他们分为 MVI 阳性、MVI 阴性、高分级和低分级组。
175 例 HCC 患者的 AFP 在 MVI 阳性和阴性组、低分级和高分级组之间存在统计学差异（P=0.002 和 0.03）。MVI 阳性和高分级组中多发 HCC 病变更为常见，而 MVI 阴性和低分级组中则更为常见单发性病变（P=0.005 和 0.019）。MRI 上的包膜在 MVI 阴性和高分级组中更为常见，差异具有统计学意义（P=0.02 和 0.011）。MVI 阳性和阴性组之间存在三种 MRI 征象的分布差异：艺术边缘增强、艺术周边增强和肿瘤边缘（P=0.001、<0.001 和<0.001）。HBP 上肿瘤低信号在 MVI 阳性和阴性组之间有显著差异（P<0.001）。
我们的研究表明，术前增强成像可用于预测 HCC 的 MVI 和肿瘤分化程度。MVI 阴性组的预后优于 MVI 阳性组。
