Shrestha Prakriti Singh, Ishak Angela, Napit Arun R, Sarwar Sarosh, Rai Niraj, Nizami Zoha, Bheemisetty Niharika, Jayaraj Prashanth, Shrestha Amardeep, Rodriguez Ivan D
Department of Research and Academic Affairs, Larkin Community Hospital, South Miami, FL, USA.
Family Medical Clinic, O'Fallon, IL, USA.
IDCases. 2022;29:e01582. doi: 10.1016/j.idcr.2022.e01582. Epub 2022 Jul 26.
Thrombosis following COVID-19 vaccination commonly occurs with vector-based vaccines. The proposed mechanism is vaccine-induced thrombotic thrombocytopenia (VITT), with thrombocytopenia as principal manifestation. We present a 51-year-old male who came with isolated portal vein thrombosis (PVT) one day after Moderna vaccination, without associated thrombocytopenia, challenging VITT as being the only patho-mechanism. Further exploration of these possible alternative mechanisms is needed for COVID-19 vaccine-related thrombotic complications.
新型冠状病毒肺炎（COVID-19）疫苗接种后的血栓形成常见于载体疫苗。推测的机制是疫苗诱导的血栓性血小板减少症（VITT），以血小板减少为主要表现。我们报告一名51岁男性，在接种Moderna疫苗一天后出现孤立性门静脉血栓形成（PVT），无相关血小板减少，这对VITT作为唯一的发病机制提出了挑战。对于与COVID-19疫苗相关的血栓并发症，需要进一步探索这些可能的替代机制。
