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使用一步法3D打印聚全氟聚醚的片上化学合成

On-Chip Chemical Synthesis Using One-Step 3D Printed Polyperfluoropolyether.

作者信息

Goralczyk Andreas, Mayoussi Fadoua, Sanjaya Mario, Corredor Santiago Franco, Bhagwat Sagar, Song Qingchuan, Schwenteck Sarah, Warmbold Andreas, Pezeshkpour Pegah, Rapp Bastian E

机构信息

University of Freiburg Laboratory of Process Technology, NeptunLab Department of Microsystems Engineering (IMTEK) Georges-Köhler-Allee 103 79110 Freiburg im Breisgau Germany.

University of Freiburg Freiburg Materials Research Center (FMF) Stefan-Meier-Straße 21 79104 Freiburg im Breisgau Germany.

出版信息

Chem Ing Tech. 2022 Jul;94(7):975-982. doi: 10.1002/cite.202200013. Epub 2022 Apr 25.

DOI:10.1002/cite.202200013
PMID:35915768
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9322562/
Abstract

Three-dimensional (3D) printing has already shown its high relevance for the fabrication of microfluidic devices in terms of precision manufacturing cycles and a wider range of materials. 3D-printable transparent fluoropolymers are highly sought after due to their high chemical and thermal resistance. Here, we present a simple one-step fabrication process via stereolithography of perfluoropolyether dimethacrylate. We demonstrate successfully printed microfluidic mixers with 800 µm circular channels for chemistry-on-chip applications. The printed chips show chemical, mechanical, and thermal resistance up to 200 °C, as well as high optical transparency. Aqueous and organic reactions are presented to demonstrate the wide potential of perfluoropolyether dimethacrylate for chemical synthesis.

摘要

就精密制造周期和更广泛的材料而言，三维（3D）打印已显示出其在微流控设备制造中的高度相关性。由于具有高化学和热抗性，可3D打印的透明含氟聚合物备受追捧。在此，我们展示了一种通过全氟聚醚二甲基丙烯酸酯立体光刻进行的简单一步制造工艺。我们成功展示了用于芯片化学应用的具有800μm圆形通道的微流控混合器。打印的芯片显示出高达200°C的化学、机械和热抗性，以及高光学透明度。本文展示了水性和有机反应，以证明全氟聚醚二甲基丙烯酸酯在化学合成方面的广泛潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/34d86802e97c/CITE-94-975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/d1a3eef117c6/CITE-94-975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/ee48a09ab654/CITE-94-975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/34d86802e97c/CITE-94-975-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/d1a3eef117c6/CITE-94-975-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/ee48a09ab654/CITE-94-975-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/78bc/9322562/34d86802e97c/CITE-94-975-g003.jpg

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Sci Adv. 2021 Jun 11;7(24). doi: 10.1126/sciadv.abg3338. Print 2021 Jun.
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3D Printed Microfluidics.3D打印微流控技术
用于光子应用的紫外光发光二极管可固化全氟聚醚（PFPE）-聚氨酯甲基丙烯酸酯透明涂层：合成与表征
Polymers (Basel). 2023 Jul 8;15(14):2983. doi: 10.3390/polym15142983.
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Combining 3D Printing and Microfluidic Techniques: A Powerful Synergy for Nanomedicine.结合3D打印与微流控技术：纳米医学的强大协同作用。
Pharmaceuticals (Basel). 2023 Jan 1;16(1):69. doi: 10.3390/ph16010069.
Annu Rev Anal Chem (Palo Alto Calif). 2020 Jun 12;13(1):45-65. doi: 10.1146/annurev-anchem-091619-102649. Epub 2019 Dec 10.
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