College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, 410083, P. R. China.
Department of Chemistry and COSDAF (Centre of Super-Diamond and Advanced Films), City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong, China.
Chem Commun (Camb). 2022 Aug 18;58(67):9425-9428. doi: 10.1039/d2cc03592h.
Herein, two mitochondria-targeting photosensitizers (PSs, CCVJ-Mito-1 and CCVJ-Mito-2) that exhibit a turn-on fluorescence response towards increasing viscosity are reported. Notably, CCVJ-Mito-2 exhibits absorption in the near-infrared (NIR) region, and can be employed as a NIR PS targeting mitochondria and a fluorescent probe for tracking mitochondrial viscosity changes during photodynamic therapy (PDT). This dual functional PS can help to shed light on the dynamic changes of the cellular microenvironment during PDT and further guide the PDT process.
本文报道了两种靶向线粒体的光动力治疗敏化剂（PSs），即 CCVJ-Mito-1 和 CCVJ-Mito-2，它们在粘度增加时具有荧光响应的开启特性。值得注意的是，CCVJ-Mito-2 在近红外（NIR）区域具有吸收，可作为靶向线粒体的 NIR PS 和用于跟踪光动力治疗（PDT）过程中线粒体粘度变化的荧光探针。这种双功能 PS 有助于阐明 PDT 过程中细胞微环境的动态变化，并进一步指导 PDT 过程。
