Department of Dermatology and Venerology, National Clinical Research Center for Geriatrics, Sichuan University West China Hospital, Chengdu, China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-Related Molecular Network, Sichuan University West China Hospital, Chengdu, China.
Dermatol Surg. 2022 Aug 1;48(8):797-801. doi: 10.1097/DSS.0000000000003506. Epub 2022 Jun 21.
Sebaceous adenocarcinoma (SAC) mostly occurs in the elderly, and SAC in young and middle-aged population is inadequately investigated.
To explore the clinical features and prognosis of young and middle-aged adults with SAC.
Patients with skin SAC between ages 18 and 59 years from the Surveillance, Epidemiology, and End Results database (1975-2016) were eligible for this study.
Seven hundred thirty-nine cases were identified. The proportion of extraocular SAC in the nonelderly increased from 1975-2005 to 2006-2016 ( p = .001), male predominance was observed in overall patients whereas female predominance in Asian population, and young patients had more head and neck SAC than middle-aged patients ( p = .014). The prognosis of young patients was better than middle-aged patients ( p = .004). Other independent prognostic factors included sex, marital status, tumor size, surgery, chemotherapy, and multiple primary cancer history.
An increasing proportion of extraocular SAC was observed in young and middle-aged patients, and the young developed more head and neck SAC than the middle-aged. Female predominance was found in Asian population, and female patients had better prognosis. Younger age and married status indicated better prognosis, and around 20% of young and middle-aged patients might have poorer survival because of Muir-Torre syndrome.
皮脂腺癌（SAC）多发生于老年人，而中青年人群中的 SAC 研究不足。
探讨中青年皮脂腺癌患者的临床特征和预后。
本研究纳入了 Surveillance, Epidemiology, and End Results 数据库（1975-2016 年）中年龄在 18-59 岁的皮肤 SAC 患者。
共纳入 739 例患者。非老年患者中外眼部 SAC 的比例从 1975-2005 年增加到 2006-2016 年（p =.001），总体上男性多于女性，但在亚洲人群中女性多于男性，且年轻患者头颈部 SAC 多于中年患者（p =.014）。年轻患者的预后好于中年患者（p =.004）。其他独立的预后因素包括性别、婚姻状况、肿瘤大小、手术、化疗和多发性原发性癌症病史。
观察到中青年患者中外眼部 SAC 的比例增加，且年轻患者比中年患者更易发生头颈部 SAC。在亚洲人群中，女性多于男性，且女性患者的预后更好。年轻和已婚状态预示着更好的预后，约 20%的年轻和中年患者可能因 Muir-Torre 综合征而预后较差。
