Thakker K M, Sitren H S, Gregory J F, Schmidt G L, Baumgartner T G
Am J Clin Nutr. 1987 Jun;45(6):1472-9. doi: 10.1093/ajcn/45.6.1472.
The effects of formulation factors and pharmaceutical dosage form on the bioavailability of RRR-alpha-tocopherol (d-alpha-tocopherol), riboflavin, and pyridoxine hydrochloride were studied after administration of two capsule formulations and a tablet to 12 normal humans. Absorption of RRR-alpha-tocopherol was increased from the Aquabiosorb soft elastic gelatin (SEG) capsule formulation compared with the modified standard-SEG capsule and the commercial tablet. There were no significant differences in bioavailability of riboflavin and pyridoxine hydrochloride between the SEG formulation and the tablet albeit a trend toward consistent absorption was seen from the SEG formulation. The modified-SEG formulation exhibited significantly lower bioavailability for these water-soluble vitamins. The enhanced bioavailability of vitamin E and the trend towards faster and more consistent absorption of riboflavin and vitamin B-6 from the SEG formulation may be related to the surfactant vehicle employed and the attendant wetting properties. The results also suggest ethnic differences in vitamin bioavailability.
在给12名正常人服用两种胶囊制剂和一种片剂后，研究了制剂因素和药物剂型对RRR-α-生育酚（d-α-生育酚）、核黄素和盐酸吡哆醇生物利用度的影响。与改良标准软胶囊和市售片剂相比，Aquabiosorb软质弹性明胶（SEG）胶囊制剂中RRR-α-生育酚的吸收增加。SEG制剂和片剂之间核黄素和盐酸吡哆醇的生物利用度没有显著差异，尽管从SEG制剂中观察到吸收一致的趋势。改良SEG制剂对这些水溶性维生素的生物利用度显著较低。维生素E生物利用度的提高以及SEG制剂中核黄素和维生素B-6吸收更快且更一致的趋势可能与所使用的表面活性剂载体及其伴随的湿润特性有关。结果还表明维生素生物利用度存在种族差异。
