School of Pharmacy, Fudan University, Key Laboratory of Smart Drug Delivery, Ministry of Education, Shanghai, Zhejiang, China.
Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China.
Expert Opin Drug Deliv. 2022 Aug;19(8):965-984. doi: 10.1080/17425247.2022.2108786. Epub 2022 Aug 11.
Red blood cell (or erythrocyte) membrane-camouflaged nanoparticles (RBC-NPs) not only have a superior circulation life and do not induce accelerated blood clearance but also possess special functions, which offers great potential in cancer therapy.
This review focuses on the recent advances of RBC-NPs for delivering various agents to treat cancers in light of their vital role in improving drug delivery. Meanwhile, the construction and in vivo behavior of RBC-NPs are discussed to provide an in-depth understanding of the basis of RBC-NPs for improved cancer drug delivery.
Although RBC-NPs are quite prospective in delivering anti-cancer therapeutics, they are still in their infancy stage and many challenges need to be overcome for successful translation into the clinic. The preparation and modification of RBC membranes, the optimization of coating methods, the scale-up production and the quality control of RBC-NPs, and the drug loading and release should be carefully considered in the clinical translation of RBC-NPs for cancer therapy.
红细胞（或红细胞）膜伪装纳米颗粒（RBC-NPs）不仅具有优越的循环寿命，不会引起加速血液清除，而且还具有特殊的功能，在癌症治疗方面具有巨大的潜力。
本文重点介绍了 RBC-NPs 在递送各种药物以治疗癌症方面的最新进展，鉴于其在改善药物递送方面的重要作用。同时，讨论了 RBC-NPs 的构建和体内行为，以深入了解 RBC-NPs 改善癌症药物递送的基础。
尽管 RBC-NPs 在递送抗癌治疗药物方面具有很大的前景，但它们仍处于起步阶段，要成功转化为临床应用还需要克服许多挑战。在将 RBC-NPs 用于癌症治疗的临床转化中，应仔细考虑 RBC 膜的制备和修饰、涂层方法的优化、规模化生产和质量控制以及药物的负载和释放。
