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美国血友病患者群体中获得性免疫缺陷综合征的流行病程。

The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population.

作者信息

McGrady G A, Jason J M, Evatt B L

出版信息

Am J Epidemiol. 1987 Jul;126(1):25-30. doi: 10.1093/oxfordjournals.aje.a114657.

DOI:10.1093/oxfordjournals.aje.a114657
PMID:3591786
Abstract

The time course of the epidemic of acquired immunodeficiency syndrome (AIDS) as it has occurred in the US hemophilia population is examined using surveillance data collected by the Centers for Disease Control (CDC). These data indicate that the epidemic course in hemophiliacs is distinguishable from that in the homosexual/bisexual and intravenous drug-using populations in at least one respect--the epidemic in the hemophilia population is characterized by a lack of consistent increase in the number of new AIDS cases in successive time intervals. This difference is interpreted as being attributable to the mechanisms by which AIDS virus is spread among hemophiliacs. In addition, the short survival following diagnosis of AIDS in hemophiliacs and the magnitude of yearly incidence rates for this group in 1984 and 1985 show the hemophilia population to have been severely affected by the epidemic.

摘要

利用美国疾病控制中心(CDC)收集的监测数据,对获得性免疫缺陷综合征(AIDS)在美国血友病患者群体中的流行时间进程进行了研究。这些数据表明,血友病患者群体中的流行进程在至少一个方面与同性恋/双性恋群体及静脉注射吸毒人群有所不同——血友病患者群体中的流行特征是在连续的时间间隔内新艾滋病病例数没有持续增加。这种差异被解释为是由于艾滋病病毒在血友病患者中传播的机制所致。此外,血友病患者确诊艾滋病后的存活期较短,以及该群体在1984年和1985年的年发病率表明,血友病患者群体受到了该流行病的严重影响。

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The course of the epidemic of acquired immunodeficiency syndrome in the United States hemophilia population.美国血友病患者群体中获得性免疫缺陷综合征的流行病程。
Am J Epidemiol. 1987 Jul;126(1):25-30. doi: 10.1093/oxfordjournals.aje.a114657.
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引用本文的文献

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Foreign-protein-mediated immunodeficiency in hemophiliacs with and without HIV.有和没有感染HIV的血友病患者中由外源蛋白介导的免疫缺陷
Genetica. 1995;95(1-3):51-70. doi: 10.1007/BF01435001.
2
AIDS--A global perspective. Global epidemiology.艾滋病——全球视角。全球流行病学。
West J Med. 1987 Dec;147(6):694-701.
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Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy.齐多夫定。对其药效学和药代动力学特性以及治疗效果的综述。
Drugs. 1989 Apr;37(4):408-50. doi: 10.2165/00003495-198937040-00003.