Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN), Japan; Graduate School of Pharmaceutical Sciences, Osaka University, Japan.
Laboratory of Vaccine Materials, Center for Vaccine and Adjuvant Research, and Laboratory of Gut Environmental System, Collaborative Research Center for Health and Medicine, National Institutes of Biomedical Innovation, Health, and Nutrition (NIBIOHN), Japan.
Vaccine. 2022 Aug 26;40(36):5399-5403. doi: 10.1016/j.vaccine.2022.07.031. Epub 2022 Jul 30.
Vaccination is one of the most powerful strategies for the preventive and therapeutic control of infectious diseases and other diseases such as cancer. To maximize the effectiveness of vaccines, it is necessary to modify the immune responses by means of adjuvants. The gut environment, including commensal bacteria and dietary components, has been proven to be able to mediate host immunity. An understanding of gut microbiota-related regulation of immune responses has revealed the potential adjuvanticity of particular microbiota-derived compounds, driving exploration into their development as vaccine adjuvants. In this review, we discuss how commensal bacteria and compounds derived from them regulate host immune responses, and we propose the potential application of these compounds as vaccine adjuvants.
疫苗接种是预防和治疗传染病和癌症等其他疾病的最有力策略之一。为了最大限度地提高疫苗的效果，需要通过佐剂来改变免疫反应。肠道环境，包括共生细菌和饮食成分，已被证明能够调节宿主免疫。对肠道微生物群相关免疫反应调节的理解揭示了特定微生物衍生化合物的潜在佐剂特性，推动了将其开发为疫苗佐剂的探索。在这篇综述中，我们讨论了共生细菌及其衍生化合物如何调节宿主免疫反应，并提出了这些化合物作为疫苗佐剂的潜在应用。
