School of Life Sciences, Zhaoqing University, Zhaoqing, China.
College of Animal Science, Guizhou University, Guiyang, China.
BioDrugs. 2023 Mar;37(2):143-180. doi: 10.1007/s40259-022-00575-1. Epub 2023 Jan 6.
Over the past 20 years, a variety of potential adjuvants have been studied to enhance the effect of oral vaccines in the intestinal mucosal immune system; however, no licensed adjuvant for clinical application in oral vaccines is available. In this review, we systematically updated the research progress of oral vaccine adjuvants over the past 2 decades, including biogenic adjuvants, non-biogenic adjuvants, and their multi-type composite adjuvant materials, and introduced their immune mechanisms of adjuvanticity, aiming at providing theoretical basis for developing feasible and effective adjuvants for oral vaccines. Based on these insights, we briefly discussed the challenges in the development of oral vaccine adjuvants and prospects for their future development.
在过去的 20 年中，研究了多种潜在的佐剂以增强口服疫苗在肠道黏膜免疫系统中的效果；然而，目前尚无获准用于临床应用的口服疫苗佐剂。在本综述中，我们系统地更新了过去 20 年口服疫苗佐剂的研究进展，包括生物佐剂、非生物佐剂及其多种复合型佐剂材料，并介绍了它们的佐剂作用的免疫机制，旨在为开发可行有效的口服疫苗佐剂提供理论依据。基于这些见解，我们简要讨论了开发口服疫苗佐剂所面临的挑战和未来发展的前景。
