Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, MI, USA.
Medical Scientist Training Program, University of Michigan, Ann Arbor, MI, USA.
Hum Reprod. 2023 Oct 3;38(10):1872-1880. doi: 10.1093/humrep/dead158.
Transgender and nonbinary people with female birth sex may utilize testosterone therapy for masculinization. Individuals interested in reproduction using their own gametes should be offered fertility preservation prior to starting testosterone. However, logistical and practical barriers prevent many from accessing fertility preservation options prior to starting testosterone. Some of these transmasculine and nonbinary individuals may later become interested in carrying a pregnancy or using their oocytes for reproduction after being on testosterone. Many questions remain about the reproductive impact of long-term masculinizing testosterone therapy. Emerging literature has documented pregnancies and successful assisted reproduction for some people after taking testosterone, but it is not known whether individuals can expect these successful outcomes. Testosterone appears to impact the reproductive tract, including the ovaries, uterus, and fallopian tubes, but the reversibility and functional impact of these changes also remain unclear. A greater understanding of the impact of masculinizing testosterone on reproductive capacity remains a priority area for future research.
跨性别和非二元性别者（出生时性别为女性）可能会使用睾丸素治疗来实现男性化。对于希望使用自身配子进行生育的个体，应在开始使用睾丸素之前提供生育力保存。然而，由于各种实际和后勤方面的障碍，许多人在开始使用睾丸素之前无法获得生育力保存的选择。一些跨性别男性和非二元性别者在使用睾丸素后可能会对怀孕或使用卵子进行生育感兴趣。关于长期使用睾丸素进行男性化治疗对生殖的影响，仍存在许多问题。新出现的文献记录了一些人在使用睾丸素后成功怀孕和进行辅助生殖，但尚不清楚这些人是否可以期待这样的成功结果。睾丸素似乎会影响生殖道，包括卵巢、子宫和输卵管，但这些变化的可逆性和功能影响仍不清楚。因此，更深入地了解男性化睾丸素对生殖能力的影响仍然是未来研究的重点领域。
