Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Sci Rep. 2022 Aug 2;12(1):13231. doi: 10.1038/s41598-022-17115-0.
An updated exploration of the burden of thyroid cancer across a country is always required for making correct decisions. The objective of this study is to present the thyroid cancer burden and attributed burden to the high Body Mass Index (BMI) in Iran at national and sub-national levels from 1990 to 2019. The data was obtained from the GBD 2019 study estimates. To explain the pattern of changes in incidence from 1990 to 2019, decomposition analysis was conducted. Besides, the attribution of high BMI in the thyroid cancer DALYs and deaths were obtained. The age-standardized incidence rate of thyroid cancer was 1.57 (95% UI: 1.33-1.86) in 1990 and increased 131% (53-191) until 2019. The age-standardized prevalence rate of thyroid cancer was 30.19 (18.75-34.55) in 2019 which increased 164% (77-246) from 11.44 (9.38-13.85) in 1990. In 2019, the death rate, and Disability-adjusted life years of thyroid cancer was 0.49 (0.36-0.53), and 13.16 (8.93-14.62), respectively. These numbers also increased since 1990. The DALYs and deaths attributable to high BMI was 1.91 (0.95-3.11) and 0.07 (0.04-0.11), respectively. The thyroid cancer burden and high BMI attributed burden has increased from 1990 to 2019 in Iran. This study and similar studies' results can be used for accurate resource allocation for efficient management and all potential risks' modification for thyroid cancer with a cost-conscious view.
对一个国家的甲状腺癌负担进行更新的探索对于做出正确的决策总是必要的。本研究的目的是在国家和次国家层面上展示 1990 年至 2019 年伊朗的甲状腺癌负担和归因于高体重指数（BMI）的负担。数据来自 GBD 2019 研究估计。为了解释 1990 年至 2019 年发病率变化的模式，进行了分解分析。此外，还获得了甲状腺癌 DALYs 和死亡归因于高 BMI 的情况。1990 年，甲状腺癌的年龄标准化发病率为 1.57（95%UI：1.33-1.86），到 2019 年增加了 131%（53-191）。2019 年，甲状腺癌的年龄标准化患病率为 30.19（18.75-34.55），比 1990 年的 11.44（9.38-13.85）增加了 164%（77-246）。2019 年，甲状腺癌的死亡率和残疾调整生命年分别为 0.49（0.36-0.53）和 13.16（8.93-14.62）。这些数字自 1990 年以来也有所增加。归因于高 BMI 的 DALYs 和死亡人数分别为 1.91（0.95-3.11）和 0.07（0.04-0.11）。1990 年至 2019 年，伊朗的甲状腺癌负担和高 BMI 归因负担有所增加。本研究和类似研究的结果可用于为有效管理进行准确的资源分配，并从成本意识的角度对甲状腺癌的所有潜在风险进行修改。
