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用烟酰胺核糖平衡 NAD 缺乏：治疗的可能性和局限性。

Balancing NAD deficits with nicotinamide riboside: therapeutic possibilities and limitations.

机构信息

Nestlé Institute of Health Sciences, Nestlé Research Ltd., EPFL Campus, Innovation Park, Building G, 1015, Lausanne, Switzerland.

School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015, Lausanne, Switzerland.

出版信息

Cell Mol Life Sci. 2022 Aug 2;79(8):463. doi: 10.1007/s00018-022-04499-5.

DOI:10.1007/s00018-022-04499-5
PMID:35918544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9345839/
Abstract

Alterations in cellular nicotinamide adenine dinucleotide (NAD) levels have been observed in multiple lifestyle and age-related medical conditions. This has led to the hypothesis that dietary supplementation with NAD precursors, or vitamin B3s, could exert health benefits. Among the different molecules that can act as NAD precursors, Nicotinamide Riboside (NR) has gained most attention due to its success in alleviating and treating disease conditions at the pre-clinical level. However, the clinical outcomes for NR supplementation strategies have not yet met the expectations generated in mouse models. In this review we aim to provide a comprehensive view on NAD biology, what causes NAD deficits and the journey of NR from its discovery to its clinical development. We also discuss what are the current limitations in NR-based therapies and potential ways to overcome them. Overall, this review will not only provide tools to understand NAD biology and assess its changes in disease situations, but also to decide which NAD precursor could have the best therapeutic potential.

摘要

细胞烟酰胺腺嘌呤二核苷酸 (NAD) 水平的改变已在多种生活方式和与年龄相关的医学病症中观察到。这导致了这样一种假设，即通过膳食补充 NAD 前体或维生素 B3，可以发挥健康益处。在可以作为 NAD 前体的不同分子中，由于其在缓解和治疗临床前疾病方面的成功，烟酰胺核糖苷 (NR) 引起了最多的关注。然而，NR 补充策略的临床结果尚未达到在小鼠模型中产生的预期。在这篇综述中，我们旨在提供对 NAD 生物学、导致 NAD 缺乏的原因以及 NR 从发现到临床开发的历程的全面了解。我们还讨论了 NR 为基础的治疗方法目前存在的局限性以及克服这些局限性的潜在方法。总的来说，这篇综述不仅将提供工具来了解 NAD 生物学并评估其在疾病情况下的变化，还将决定哪种 NAD 前体具有最佳的治疗潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/a39c9976b4f6/18_2022_4499_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/c11d1961b0f9/18_2022_4499_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/3a55dc641441/18_2022_4499_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/155d30a50de7/18_2022_4499_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/a39c9976b4f6/18_2022_4499_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/c11d1961b0f9/18_2022_4499_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/3a55dc641441/18_2022_4499_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/155d30a50de7/18_2022_4499_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4035/11071971/a39c9976b4f6/18_2022_4499_Fig4_HTML.jpg

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