烟酰胺核糖三油酸酯氯化物的合成、稳定性及生物利用度

Synthesis, Stability, and Bioavailability of Nicotinamide Riboside Trioleate Chloride.

作者信息

Zarei Amin, Khazdooz Leila, Madarshahian Sara, Enayati Mojtaba, Mosleh Imann, Lin Tiantian, Yan Bing, Ufheil Gerhard, Wooster Timothy James, Abbaspourrad Alireza

机构信息

Department of Food Science, College of Agriculture and Life Sciences, Cornell University, Ithaca, NY 14853, USA.

Nestlé Product Technology Center, Nestlé Health Science, Bridgewater, NJ 08807, USA.

出版信息

Nutrients. 2021 Dec 27;14(1):113. doi: 10.3390/nu14010113.

DOI:10.3390/nu14010113

PMID:35010986

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8746687/

Abstract

Nicotinamide riboside chloride (NRCl) is an effective form of vitamin B3. However, it cannot be used in ready-to-drink (RTD) beverages or high-water activity foods because of its intrinsic instability in water. To address this issue, we synthesized nicotinamide riboside trioleate chloride (NRTOCl) as a new hydrophobic nicotinamide riboside (NR) derivative. Contrary to NRCl, NRTOCl is soluble in an oil phase. The results of stability studies showed that NRTOCl was much more stable than NRCl both in water and in oil-in-water emulsions at 25 °C and 35 °C. Finally, we evaluated the bioavailability of NRTOCl by studying its digestibility in simulated intestinal fluid. The results demonstrated that NRTOCl was partially digestible and released NR in the presence of porcine pancreatin in a simulated intestinal fluid. This study showed that NRTOCl has the potential to be used as an NR derivative in ready-to-drink (RTD) beverages and other foods and supplement applications.

摘要

氯化烟酰胺核糖苷（NRCl）是维生素B3的一种有效形式。然而，由于其在水中固有的不稳定性，它不能用于即饮（RTD）饮料或高水分活度食品中。为了解决这个问题，我们合成了氯化烟酰胺核糖苷三油酸酯（NRTOCl）作为一种新的疏水性烟酰胺核糖苷（NR）衍生物。与NRCl相反，NRTOCl可溶于油相。稳定性研究结果表明，在25℃和35℃下，NRTOCl在水和水包油乳液中的稳定性都比NRCl高得多。最后，我们通过研究NRTOCl在模拟肠液中的消化率来评估其生物利用度。结果表明，在模拟肠液中存在猪胰酶的情况下，NRTOCl可部分消化并释放出NR。这项研究表明，NRTOCl有潜力作为一种NR衍生物用于即饮（RTD）饮料以及其他食品和补充剂应用中。