Université de Paris, Inserm, Centre d'Investigation Clinique (CIC) 1417, Assistance Publique - Hôpitaux de Paris, CIC Cochin-Pasteur, Hôpital Cochin, 27 Rue du Faubourg Saint-Jacques, Paris, France.
Centre International de Recherche en Infectiologie, Team GIMAP, Université de Lyon, Université Jean Monnet, Université Claude Bernard Lyon 1, Inserm, U111, Centre National de Recherche Scientifique (CNRS), Unité mixte de recherche (UMR) 530, Lyon, France.
BMC Geriatr. 2022 Aug 2;22(1):637. doi: 10.1186/s12877-022-03338-3.
In France, the increase in COVID-19 vaccine uptake among older adults slowed down between May and June 2021. Using the data from a national survey, we aimed to assess COVID-19 vaccine uptake among French residents aged 65 years and older, particularly at risk of severe form of the infection, and identify factors associated with non-vaccination.
A cross-sectional online survey collected the immunization status/intention to get the COVID-19 vaccine, reasons for vaccination/non-vaccination and factors potentially associated with vaccine uptake between May 10 and 23, 2021 among a large sample of French residents. Characteristics of participants were compared according to immunization status. Factors potentially associated with non-vaccination were computed into a multivariate logistic regression.
Among the 1941 survey participants, 1612 (83%) reported having received at least one dose of COVID-19 vaccine. Among the 329 unvaccinated, 197 (60%) declared having the intention to get vaccinated. Younger age (adjusted odds ratio (aOR) = 1.50; 95% confidence interval (CI), 1.05-2.14), thinking previously having COVID-19 (aOR = 4.01; 95% CI, 2.17-7.40), having suffered economic impact due to the pandemic (aOR = 2.63; 95% CI, 1.71-4.04), reporting an "unsafe" opinion about COVID-19 vaccine safety (aOR = 6.79; 95% CI, 4.50-10.26), reporting an "unsupportive" opinion about vaccination in general (aOR = 4.24; 95% CI, 2.77-6.49) were independent risk factors for non-vaccination. On the other hand, trust in COVID-19 vaccine information delivered by the doctor (aOR = 0.28; 95% CI, 0.16-0.48) and trust in the government's actions (aOR = 0.50; 95% CI, 0.34-0.74) were independent protective factors for non-vaccination. Political affiliation also remained significantly associated with vaccine uptake.
Despite high overall COVID-19 vaccine uptake among the study participants, differences in vaccine uptake according to the level of concerns regarding COVID-19 vaccine safety, socioeconomic profile and trust in the government were observed. Our results reinforce the importance of "reaching out" vaccination strategy that specifically targets the most vulnerable fringe of older adult population.
2021 年 5 月至 6 月期间，法国老年人的 COVID-19 疫苗接种率增长放缓。本研究使用全国性调查数据，旨在评估有感染严重疾病风险的法国 65 岁及以上老年人的 COVID-19 疫苗接种情况，并确定与未接种疫苗相关的因素。
2021 年 5 月 10 日至 23 日期间，我们通过一项横断面在线调查，收集了大量法国居民的疫苗接种状况/接种 COVID-19 疫苗的意愿、接种/未接种疫苗的原因以及与疫苗接种率相关的潜在因素。根据免疫状况对参与者的特征进行了比较。将潜在的与未接种疫苗相关的因素纳入多变量逻辑回归。
在 1941 名调查参与者中，1612 名（83%）报告至少接种了一剂 COVID-19 疫苗。在 329 名未接种疫苗的人中，197 名（60%）表示有接种疫苗的意愿。较年轻的年龄（调整后的优势比（aOR）=1.50；95%置信区间（CI），1.05-2.14）、认为之前曾感染过 COVID-19（aOR=4.01；95%CI，2.17-7.40）、因大流行而遭受经济影响（aOR=2.63；95%CI，1.71-4.04）、对 COVID-19 疫苗安全性持“不安全”意见（aOR=6.79；95%CI，4.50-10.26）、对一般接种疫苗持“不支持”意见（aOR=4.24；95%CI，2.77-6.49）是未接种疫苗的独立危险因素。另一方面，对医生提供的 COVID-19 疫苗信息的信任（aOR=0.28；95%CI，0.16-0.48）和对政府行动的信任（aOR=0.50；95%CI，0.34-0.74）是未接种疫苗的独立保护因素。政治派别也与疫苗接种率显著相关。
尽管研究参与者的 COVID-19 疫苗总体接种率较高，但根据对 COVID-19 疫苗安全性、社会经济状况和对政府信任的关注程度，疫苗接种率存在差异。我们的研究结果强调了“主动出击”接种策略的重要性，该策略专门针对最脆弱的老年人群体。
