在坦桑尼亚姆库兰加区，经过五轮吡喹酮大规模药物治疗后，小学生持续性传播的流行情况及相关因素：一项横断面研究。

Prevalence and factors associated with persistent transmission of primary school children after five rounds of mass drug administration using praziquantel: A cross sectional study in Mkuranga district, Tanzania.

机构信息

Department of Parasitology and Medical Entomology, Muhimbili University of Health and Allied Sciences, Dar es salaam, Tanzania.

Department of Biochemistry and Molecular Biology, 108082Hubert Kairuki Memorial University, Dar es salaam, Tanzania.

出版信息

Trop Doct. 2022 Oct;52(4):526-531. doi: 10.1177/00494755221103088. Epub 2022 Aug 2.

DOI:10.1177/00494755221103088

PMID:35918841

Abstract

Despite a human schistosomiasis control programme through praziquantel mass drug administration (MDA) between 2011 and 2015,there was still persistent transmission among primary schoolchildren (PSC) in Mkuranga district, Tanzania. Our cross-sectional study was conducted among 396 PSC who provided urine for diagnosis of infection. Observations were conducted to determine PSC water contact activities. Logistic regression was used to test association between dependent and independent variables. We found MDA uptake among PSC as 72.5%, and the prevalence of infection 5.8%. The risk of infection increased among PSC engaged in fetching water and adjusted odds ratio (AOR) for swimming, bathing, fishing, crossing ponds and paddy fields were 0.123, 0.166, 0.232, 0.202 and 0.093 respectively. Thus we conclude that multiple water contact activities and low participation in MDA is responsible for persistent transmission.

摘要

尽管在 2011 年至 2015 年期间通过吡喹酮大规模药物治疗（MDA）实施了人类血吸虫病控制计划，但坦桑尼亚姆库兰加区的小学生（PSC）中仍存在持续传播。我们的横断面研究在 396 名提供尿液进行感染诊断的 PSC 中进行。观察结果用于确定 PSC 的水接触活动。逻辑回归用于测试因变量和自变量之间的关联。我们发现 PSC 中的 MDA 吸收率为 72.5%，感染率为 5.8%。从事取水活动的 PSC 感染风险增加，游泳、洗澡、钓鱼、穿越池塘和稻田的调整后的优势比（AOR）分别为 0.123、0.166、0.232、0.202 和 0.093。因此，我们得出结论，多种水接触活动和 MDA 参与率低是持续传播的原因。