Liu Donglei, Zhang Jiaxing, You Chuanrui, Chen Hui, Shan Zhihua
National Engineering Laboratory for Clean Technology of Leather Manufacture, Sichuan University Chengdu 610000 China
RSC Adv. 2022 Jul 14;12(31):20403-20411. doi: 10.1039/d2ra02111k. eCollection 2022 Jul 6.
The molecular weight of collagen-degrading polypeptides (CDPs) extracted using the alkali method from leather scraps must be expanded to improve its utilization effect. A novel polymer (CPP) was synthesized from tricyanogen chloride (TC) and CDP by mechanical force without water. According to the solution viscosity and content of water-soluble matter, the optimal condensation conditions of the (TC)/(CDP) and temperature were obtained and the properties of CPP, such as the molecular weight, thermal properties, and isoelectric point were tested and analyzed. The synthesis of CPP was simulated by the substitution of l-threonine containing hydroxyl and amino groups for the condensation reaction of CDP and TC. The result illustrated that only amino groups were involved in the substitution of chlorine accomplished by the SN2 pathway. Based on this, a probable formation mechanism of CPP was proposed. As an illustration, CPP has good utilization values in the preparation of a corrugated paper jelly instead of gelatin. The preparation of polypeptide water-based adhesive by a mechanochemical method not only has good controllability in the production process but also can save water and energy.
采用碱法从皮革废料中提取的胶原蛋白降解多肽（CDPs）的分子量必须扩大，以提高其利用效果。通过机械力在无水条件下由三聚氯氰（TC）和CDP合成了一种新型聚合物（CPP）。根据溶液粘度和水溶性物质含量，得出了（TC）/（CDP）与温度的最佳缩合条件，并对CPP的分子量、热性能和等电点等性质进行了测试和分析。通过用含有羟基和氨基的L-苏氨酸替代CDP和TC的缩合反应，模拟了CPP的合成。结果表明，只有氨基参与了通过SN2途径完成的氯取代反应。基于此，提出了CPP可能的形成机制。作为例证，CPP在制备瓦楞纸胶冻而非明胶方面具有良好的利用价值。采用机械化学方法制备多肽水基胶粘剂，不仅在生产过程中具有良好的可控性，而且可以节约用水和能源。
