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在渗透瞬变期间对灌注兔心脏测量组织液压力。

Tissue-fluid pressure measured in perfused rabbit hearts during osmotic transients.

作者信息

Anderson S E, Johnson J A

出版信息

Am J Physiol. 1987 Jun;252(6 Pt 2):H1127-37. doi: 10.1152/ajpheart.1987.252.6.H1127.

DOI:10.1152/ajpheart.1987.252.6.H1127
PMID:3591965
Abstract

To resolve discrepancies between models used to calculate myocardial capillary solute permeability we measured tissue-fluid pressure (Pi), perfusion pressure (Pp), and heart weight continuously after a step change in the NaCl or inulin concentration of crystalloid solutions perfusing isolated rabbit hearts. Linear regression analysis of the mean values for near steady-state Pi plotted against Pp showed significantly different (P less than 0.01) slopes of 0.77 and 0.40, respectively, for the inner and outer halves of the left ventricular free wall. Tissue compliance (Tcm) was measured as the fractional change in whole heart weight divided by the concurrent change in Pi. For NaCl and inulin osmotic transients Tcm values were 0.005 +/- 0.001 (SE) and 0.014 +/- 0.004 ml X cmH2O-1 X g tissue-1, respectively. A model for heart weight change based on the Starling hypothesis predicts significantly different tissue compliance (Tcc) values of 0.031 +/- 0.004 and 0.040 +/- 0.005 ml X cmH2O-1 X g tissue-1 for the same transients, respectively. This model shows myocardial capillary permeability for inulin and NaCl are overestimated by 25% if tissue compliance is not included in the analysis. The discrepancy between Tcm and Tcc is discussed.

摘要

为解决用于计算心肌毛细血管溶质通透性的模型之间的差异,我们在灌注离体兔心脏的晶体溶液中NaCl或菊粉浓度发生阶跃变化后,连续测量组织液压力(Pi)、灌注压力(Pp)和心脏重量。将接近稳态Pi的平均值与Pp进行线性回归分析,结果显示左心室游离壁内、外两半的斜率分别为0.77和0.40,差异显著(P<0.01)。组织顺应性(Tcm)的测量方法是全心重量的分数变化除以Pi的同时变化。对于NaCl和菊粉的渗透瞬变,Tcm值分别为0.005±0.001(SE)和0.014±0.004 ml·cmH2O-1·g组织-1。基于斯塔林假说的心脏重量变化模型预测,对于相同的瞬变,组织顺应性(Tcc)值分别为0.031±0.004和0.040±0.005 ml·cmH2O-1·g组织-1,差异显著。该模型表明,如果在分析中不包括组织顺应性,菊粉和NaCl的心肌毛细血管通透性将被高估25%。文中讨论了Tcm和Tcc之间的差异。

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