Heidari Toktam, Batavani Rooz Ali, Malekinejad Hassan, Hobbenaghi Rahim
Department of Theriogenology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Department of Pharmacology and Toxicology, School of Pharmacy, Urmia University of Medical Sciences, Urmia, Iran.
Vet Res Forum. 2022 Jun;13(2):201-208. doi: 10.30466/vrf.2020.118147.2806. Epub 2022 Jun 15.
Phthalates are environmental contaminants mostly used as plasticizers and additives in different products. Having endocrine-disrupting properties, phthalates are known as potential reproductive toxicants. The present study was conducted to evaluate the reproductive toxicity of di-n-butyl phthalate (DBP) in pregnant rats and their offspring and also to assess the ability of vitamin E in the elimination or reducing reproductive toxicity of DBP. Sixty-six pregnant Wistar rats were exposed to 100, 500 or 1,000 mg kg per day DBP or 500 mg kg per day DBP along with 100 mg kg per day vitamin E during gestation. After delivery, they were divided into two groups. In one group gavage was finished after litter while in the other DBP administration was continued till weaning. The results showed that DBP affected many aspects of reproductive performance in pregnant rats and their offspring. It could be suggested that vitamin E could ameliorate the adverse effects of DBP, especially in male pups.
邻苯二甲酸盐是环境污染物，主要用作不同产品中的增塑剂和添加剂。邻苯二甲酸盐具有内分泌干扰特性，被认为是潜在的生殖毒物。本研究旨在评估邻苯二甲酸二丁酯（DBP）对怀孕大鼠及其后代的生殖毒性，并评估维生素E消除或降低DBP生殖毒性的能力。66只怀孕的Wistar大鼠在妊娠期每天暴露于100、500或1000毫克/千克的DBP，或每天500毫克/千克的DBP加100毫克/千克的维生素E。分娩后，它们被分为两组。一组在产仔后停止灌胃，另一组继续给予DBP直至断奶。结果表明，DBP影响怀孕大鼠及其后代生殖性能的多个方面。可以认为，维生素E可以改善DBP的不良影响，尤其是对雄性幼崽。
