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《简易健康检查表总分对日本老年人功能性残疾发生率的预测能力:一项 8 年前瞻性研究》

Predictive ability of the total score of the Kihon checklist for the incidence of functional disability in older Japanese adults: An 8-year prospective study.

机构信息

Department of Rehabilitation Center, Fukuoka Mirai Hospital, Fukuoka, Japan.

Department of Behavior and Health Sciences, Graduate School of Human-Environment Studies, Kyushu University, Fukuoka, Japan.

出版信息

Geriatr Gerontol Int. 2022 Sep;22(9):723-729. doi: 10.1111/ggi.14435. Epub 2022 Aug 2.

Abstract

AIM

To investigate the association between the total score of the Kihon checklist (t-KCL score) and functional disability over an 8-year follow-up period, and to examine whether the t-KCL score in the basic model with risk factors contributes to the incremental predictive ability for functional disability among older adults.

METHODS

We followed 2209 older adults aged ≥65 years without functional disability at baseline. The t-KCL score was determined using a baseline survey questionnaire. Functional disability was defined based on information from long-term care certifications. The association between the t-KCL score and functional disability was examined using the Cox proportional hazards model. The incremental predictive ability of the t-KCL score for functional disability was evaluated by the difference of the C-statistic, category-free net reclassification improvement (NRI), and integrated discrimination improvement (IDI).

RESULTS

The median follow-up period was 7.8 years, and 557 participants developed functional disability. The adjusted hazard ratio (95% confidence interval [CI]) of functional disability for a 1-point increase of the t-KCL score was 1.08 (1.06-1.10). Adding the t-KCL score to the basic model significantly improved the C-statistic (95% CI) from 0.747 (0.728-0.768) to 0.760 (0.741-0.781). When the t-KCL score was added to the basic model, the NRI and IDI were 0.187 (95% CI: 0.095-0.287) and 0.020 (95% CI: 0.012-0.027), respectively.

CONCLUSIONS

The t-KCL score had an independent positive association with functional disability over an 8-year follow-up. Furthermore, adding the t-KCL score to the basic model improved the predictive ability for functional disability. Geriatr Gerontol Int 2022; 22: 723-729.

摘要

目的

探讨基本检查表总分(t-KCL 评分)与 8 年随访期间功能障碍之间的关联,并检验基本模型中包含危险因素的 t-KCL 评分是否有助于增加对老年人功能障碍的预测能力。

方法

我们随访了 2209 名基线时无功能障碍的≥65 岁老年人。t-KCL 评分通过基线调查问卷确定。根据长期护理认证信息定义功能障碍。使用 Cox 比例风险模型检验 t-KCL 评分与功能障碍之间的关联。通过 C 统计量差值、类别自由净重新分类改善(NRI)和综合判别改善(IDI)评估 t-KCL 评分对功能障碍的增量预测能力。

结果

中位随访期为 7.8 年,557 名参与者出现功能障碍。t-KCL 评分每增加 1 分,功能障碍的调整后风险比(95%置信区间[CI])为 1.08(1.06-1.10)。将 t-KCL 评分加入基本模型后,C 统计量(95%CI)显著提高,从 0.747(0.728-0.768)提高到 0.760(0.741-0.781)。当 t-KCL 评分加入基本模型时,NRI 和 IDI 分别为 0.187(95%CI:0.095-0.287)和 0.020(95%CI:0.012-0.027)。

结论

t-KCL 评分与 8 年随访期间的功能障碍呈独立正相关。此外,将 t-KCL 评分加入基本模型可提高对功能障碍的预测能力。国际老年医学与老年学杂志 2022;22:723-729。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a325/11503543/7841b8b856f1/GGI-22-723-g001.jpg

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