Kartal Dr. Lütfi Kirdar City Hospital, Department of Pediatric Endocrinology, Istanbul 34890, Turkey.
Acıbadem Mehmet Ali Aydınlar University, Faculty of Medicine, Department of Pediatric Hematology, İstanbul 34662, Turkey.
J Trop Pediatr. 2022 Jun 6;68(4). doi: 10.1093/tropej/fmac063.
The studies evaluating cases with type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in the adult population reported hyperreactive platelets and increased activation of prothrombotic factors, resulting in an increased risk of thrombosis. The aim of this study was to evaluate the effects of poor glycemic control and the duration of diabetes on platelet parameters in pediatric population.
The study included 366 children, out of which 144 (39.3%) were included in the T1DM group and 222 (60.6%) in the healthy control group. The platelet count, mean platelet volume (MPV), platelet distribution width and plateletcrit values were recorded. The children with T1DM were divided into three groups as per their glycated hemoglobin (HbA1c) levels, good (<7.5%), moderate (7.5-9%) and poor metabolic control (>9%).
No significant difference in the MPV level between the T1DM (7.41 ± 1.49 fl) and control (7.15 ± 1.23 fl) groups was observed. However, the MPV levels were significantly higher in the poor glycemic control group than in the healthy control group (p = 0.026). Furthermore, as the duration of diabetes and HbA1c levels increased, the MPV levels also increased (p < 0.001, p = 0.441).
This study suggested as the duration of diabetes and HbA1c levels increased, the MPV levels also increases. Evaluation of hematological parameters can be a cheap and useful method in the evaluation of diabetes regulation in patients with diabetes.
评估成年人群中 1 型糖尿病（T1DM）和 2 型糖尿病（T2DM）病例的研究报告称，血小板反应过度，促血栓形成因子的活性增加，导致血栓形成风险增加。本研究旨在评估血糖控制不佳和糖尿病病程对儿科人群血小板参数的影响。
该研究纳入了 366 名儿童，其中 144 名（39.3%）纳入 T1DM 组，222 名（60.6%）纳入健康对照组。记录血小板计数、平均血小板体积（MPV）、血小板分布宽度和血小板比容值。根据糖化血红蛋白（HbA1c）水平，将 T1DM 患儿分为三组，即血糖控制良好（<7.5%）、中等（7.5-9%）和差（>9%）。
T1DM 组（7.41±1.49 fl）和对照组（7.15±1.23 fl）的 MPV 水平无显著差异。然而，血糖控制不佳组的 MPV 水平明显高于健康对照组（p=0.026）。此外，随着糖尿病病程和 HbA1c 水平的增加，MPV 水平也随之升高（p<0.001，p=0.441）。
本研究表明，随着糖尿病病程和 HbA1c 水平的增加，MPV 水平也随之升高。评估血液学参数可能是评估糖尿病患者血糖控制的一种廉价且有用的方法。
