平均血小板体积水平在早产儿生发基质出血-脑室内出血中的预后价值
The prognostic value of mean platelet volume levels in germinal matrix hemorrhage- intraventricular hemorrhage in preterm infants.
作者信息
Varal Ipek Guney, Celik Ezgi Deniz Acar, Dogan Pelin, Tunc Gaffari, Oren Ayse
机构信息
Ipek Guney Varal Division of Neonatology, Department of Paediatrics, University of Health Sciences, Bursa Yuksek Ihtisas Teaching Hospital, Bursa, Turkey.
Ezgi Deniz Acar Celik Department of Paediatrics, University of Health Sciences, Bursa Yuksek Ihtisas Teaching Hospital, Bursa, Turkey.
出版信息
Pak J Med Sci. 2025 Apr;41(4):1145-1150. doi: 10.12669/pjms.41.4.11642.
OBJECTIVE
Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) is currently the most significant cause of brain damage and mortality seen in preterm infants. The aim of this study was to evaluate the predictive value of mean platelet volume (MPV) in diagnosing GMH-IVH and mortality.
METHOD
A retrospective-cohort study of preterm infants with a gestational age <32 weeks or with birthweight <1500gr who were admitted to the Neonatal Intensive Care Unit was conducted between January 2020 and January 2022. These infants were then classified into two groups according to the presence of GMH-IVH.
RESULTS
Overall, 136 preterm infants were enrolled. The MPV levels were significantly higher in the GMH-IVH group (p <0.001). A MPV cutoff of >9.95 was determined to be predictive for GMH-IVH with sensitivity of 62% and specificity of 80% (p < 0.001). Mortality was significantly higher in the GMH-IVH group (p<0.001). A MPV cutoff of >10.55 fL was determined to predict mortality with 77% sensitivity and 70% specificity (p < 0.001).
CONCLUSIONS
The MPV value is significantly higher in infants with GMH-IVH and therefore can be used in the prediction of GMH-IVH and mortality in preterm infants.
目的
生发基质出血和脑室内出血（GMH-IVH）是目前早产儿脑损伤和死亡的最主要原因。本研究的目的是评估平均血小板体积（MPV）在诊断GMH-IVH和预测死亡率方面的价值。
方法
对2020年1月至2022年1月入住新生儿重症监护病房的胎龄<32周或出生体重<1500克的早产儿进行回顾性队列研究。然后根据是否存在GMH-IVH将这些婴儿分为两组。
结果
总共纳入了136例早产儿。GMH-IVH组的MPV水平显著更高（p<0.001）。确定MPV临界值>9.95可预测GMH-IVH，敏感性为62%，特异性为80%（p<0.001）。GMH-IVH组的死亡率显著更高（p<0.001）。确定MPV临界值>10.55 fL可预测死亡率，敏感性为77%，特异性为70%（p<0.001）。
结论
GMH-IVH婴儿的MPV值显著更高，因此可用于预测早产儿的GMH-IVH和死亡率。
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