Baek Ae-Rin, Choo Eun Ju, Kim Ji-Yeon, Ha Tae Sun, Park Sung Woo, Shin Hee Bong, Park Seong Kyu, Park Joo Hyun, Kim Tark
Division of Allergy and Pulmonary Medicine, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Division of Infectious Disease, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea.
Infect Chemother. 2022 Sep;54(3):553-558. doi: 10.3947/ic.2020.0089. Epub 2022 Jun 22.
A 65-year-old male patient with an end-stage renal disease was diagnosed with coronavirus disease 2019 (COVID-19) by reverse transcription polymerase chain reaction. The patient complained of cough, sputum, and respiratory distress that worsened three days ago. The patient required mechanical ventilation and extracorporeal mentrane oxygenation. On day 9, convalescent plasma collected from a 34-year old man who recovered from COVID-19 45 days ago was administered. The patient showed immediate clinical improvement. However, on day 14, the patient's clinical course worsened again. On day 19 and day 24, vancomycin-resistant bacteremia and methicillin-resistant pneumonia were found. After long-term supportive care, he slowly recovered. He was discharged on day 91 without any oxygen requirement. This case report suggests that convalescent plasma therapy might just provide a short-term relief and that persistent effort for critical care is necessary to save patients from severe COVID-19.
一名65岁的终末期肾病男性患者通过逆转录聚合酶链反应被诊断为2019冠状病毒病（COVID-19）。患者主诉咳嗽、咳痰和呼吸窘迫，症状在三天前加重。患者需要机械通气和体外膜肺氧合。在第9天，给予了从一名45天前从COVID-19康复的34岁男性采集的康复期血浆。患者立即出现临床改善。然而，在第14天，患者的临床病程再次恶化。在第19天和第24天，发现了耐万古霉素菌血症和耐甲氧西林肺炎。经过长期的支持治疗，他慢慢康复。他在第91天出院，无需吸氧。本病例报告表明，康复期血浆疗法可能只是提供短期缓解，对于重症COVID-19患者，持续的重症监护努力对于挽救患者生命是必要的。
