首次全合成 daphnicyclidin A 的 ABCE 环母核。
First synthesis of an ABCE ring substructure of daphnicyclidin A.
机构信息
Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
出版信息
Org Biomol Chem. 2022 Aug 24;20(33):6547-6549. doi: 10.1039/d2ob01246d.
PMID:35920311
Abstract
The ABCE tetracyclic ring system of daphnicyclidin A was prepared using an intramolecular (4 + 3) cycloaddition of an oxidopyridinium ion as the key step. This route consists of a 10-step synthesis with an overall yield of 20.2%. This result offers support for the use of this strategy for total synthesis of daphnicyclidin A.
摘要
daphnicyclidin A 的 ABCE 四环体系是通过氧化吡啶鎓离子的分子内（4 + 3）环加成反应作为关键步骤来制备的。该路线包括 10 步合成，总收率为 20.2%。这一结果为 daphnicyclidin A 的全合成采用这一策略提供了支持。
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