丁型肝炎（DELTA）。

Hepatitis D (DELTA).

机构信息

Honorary Professor of Gastroenterology, Gastrohepatology Unit, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Torino, Italy

出版信息

New Microbiol. 2022 Jul;45(3):149-154.

PMID:35920869

Abstract

The hepatitis D virus (HDV) is unique in animal virology. It is the smallest of human pathogens, re- quires the HBsAg capsid of the hepatitis B virus (HBV) to assembly into infectious virions, and parasitizes the transcriptional machinery of the host. Hepatitis D is ubiquitous but prevalence varies throughout the world. It is the most severe form of chronic viral liver disorder. Vaccination against the HBV has decreased the circulation of HDV in industrialized countries but Hepatitis D remains a significant medical issue in many areas of the developing world.

摘要

丁型肝炎病毒（HDV）在动物病毒学中是独一无二的。它是人类病原体中最小的，需要乙型肝炎病毒（HBV）的 HBsAg 衣壳才能组装成感染性病毒颗粒，并寄生于宿主的转录机制。丁型肝炎是普遍存在的，但在世界各地的流行情况有所不同。它是最严重的慢性病毒性肝脏疾病形式。乙型肝炎疫苗的接种减少了工业化国家中 HDV 的传播，但在发展中国家的许多地区，丁型肝炎仍然是一个重大的医学问题。