Cancer Research Center, School of Medicine, Xiamen University, Xiang'an South Road, Xiang'an District, Xiamen, 361102, Fujian, China.
Department of Basic Medicine, School of Medicine, Xiamen University, Xiang'an South Road, Xiang'an District, Xiamen, 361000, China.
J Mol Histol. 2022 Oct;53(5):781-791. doi: 10.1007/s10735-022-10093-7. Epub 2022 Aug 3.
Aldo-keto reductase family one, member B10 (AKR1B10) has been reported to be involved in the tumorigenesis of various cancers. It has been reported that colorectal cancer is closely associated with chronic inflammation, but the underlying molecular mechanisms are still elusive. In our study, we evaluated the relationship between AKR1B10 expression and clinicopathological characteristics of colon cancer and showed that AKR1B10 expression was significantly correlated with the T stage and clinical stage of colon cancer. Knockdown of AKR1B10 significantly decreased the expression of the inflammatory cytokines IL1α and IL6 induced by lipopolysaccharide by inhibiting the NF-κB signaling pathway. Furthermore, AKR1B10 depends on its reductase activity to affect the NF-κB signaling pathway and subsequently affect the production of inflammatory cytokines. In addition, knockdown of AKR1B10 effectively reduced cell proliferation and clonogenic growth, indicating the biological role of AKR1B10 in colon cancer. Together, our findings provide important insights into a previously unrecognized role of AKR1B10 in colon cancer.
醛酮还原酶家族 1 成员 B10（AKR1B10）已被报道参与多种癌症的肿瘤发生。据报道，结直肠癌与慢性炎症密切相关，但潜在的分子机制仍不清楚。在我们的研究中，我们评估了 AKR1B10 表达与结肠癌临床病理特征之间的关系，并表明 AKR1B10 表达与结肠癌的 T 分期和临床分期显著相关。AKR1B10 的敲低显著降低了脂多糖诱导的炎症细胞因子 IL1α 和 IL6 的表达，抑制了 NF-κB 信号通路。此外，AKR1B10 依赖其还原酶活性影响 NF-κB 信号通路，进而影响炎症细胞因子的产生。此外，AKR1B10 的敲低有效降低了细胞增殖和集落形成生长，表明 AKR1B10 在结肠癌中的生物学作用。总之，我们的研究结果为 AKR1B10 在结肠癌中的作用提供了重要的新见解。
