School of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, Metallic Materials Surface Functionalization Engineering Research Center of Guangdong Province, South China University of Technology, Guangzhou 510641, China.
School of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650093, China.
ACS Appl Mater Interfaces. 2022 Aug 17;14(32):36966-36979. doi: 10.1021/acsami.2c11503. Epub 2022 Aug 3.
Bacterial infection greatly affects the rate of wound healing. Both photothermal and photodynamic antibacterial therapies activated by near-infrared (NIR) light with semiconductor nanomedicine are two effective approaches to address bacterial infections, but they cannot coexist synergistically to kill bacteria more efficiently because of the limitation of the band structure. Here, inspired by the natural core-shell structure and photosynthesis simultaneously, polypyrrole (PPy) is synthesized in the two-dimensional restricted area of the layered bismuth oxychloride (BiOCl) nanosheets through the ultrasonic recombination method. The atomic-level interface contact and bonding formed in the PPy-BiOCl intercalated nanosheets not only improve the light-to-heat conversion capabilities of PPy but also promote the transmission of PPy photogenerated charge carriers to the BiOCl semiconductor. The nanocomposites take advantage of the deeper tissue penetration under NIR light irradiation and exhibit excellent photothermal and photodynamic synergistic antibacterial activity. In addition, PPy-BiOCl intercalated nanosheets have good biocompatibility and accelerate wound healing through their antimicrobial activity and skin repair function. The space-confined synthesis of thin PPy nanosheets in layered structures offers an efficient NIR photoresponsive nanomedicine for the treatment of pathogen infection, with promising applications in infected wound healing.
细菌感染极大地影响了伤口愈合的速度。近红外（NIR）光激活的光热和光动力抗菌疗法与半导体纳米医学是两种有效解决细菌感染的方法，但由于带结构的限制，它们不能协同作用以更有效地杀死细菌。在这里，受天然核壳结构和光合作用的启发，通过超声重组法在层状氯氧化铋（BiOCl）纳米片的二维受限区域中合成了聚吡咯（PPy）。在 PPy-BiOCl 插层纳米片中形成的原子级界面接触和键合不仅提高了 PPy 的光热转换能力，还有助于 PPy 光生载流子向 BiOCl 半导体的传输。纳米复合材料利用 NIR 光照射下更深的组织穿透，表现出优异的光热和光动力协同抗菌活性。此外，PPy-BiOCl 插层纳米片具有良好的生物相容性，并通过其抗菌活性和皮肤修复功能加速伤口愈合。在层状结构中空间限制合成的薄 PPy 纳米片为治疗病原体感染提供了一种高效的 NIR 光响应纳米医学方法，在感染性伤口愈合方面具有广阔的应用前景。
