Uhlin T, Nordvall S L, Ohman S, Einarsson R
Allergy. 1987 Apr;42(3):222-9. doi: 10.1111/j.1398-9995.1987.tb02203.x.
Fourteen patients with a known honey bee venom (HBV) allergy were followed during 1-2 years of immunotherapy. HBV-specific IgG antibody levels increased in all patients but one. HBV-specific IgE antibodies decreased slightly during the first year of therapy. The ratio HBV-specific IgG-/IgE showed a marked increase during the first year for most of the patients, and a further increase during the second year in the four patients followed that long. As could be expected an increased radiostaining was found after 1 year of treatment to all important allergens in IgG CRIE, but after 2 years a sustained or increased radiostaining was obtained to phospholipase (PLA) alone. A decreased radiostaining might more easily be seen with weaker immunogens.
14名已知对蜜蜂毒液（HBV）过敏的患者在1至2年的免疫治疗期间接受了随访。除1名患者外，所有患者的HBV特异性IgG抗体水平均有所升高。在治疗的第一年，HBV特异性IgE抗体略有下降。对于大多数患者，HBV特异性IgG/IgE比值在第一年显著升高，而在接受长达两年随访的4名患者中，该比值在第二年进一步升高。正如预期的那样，在IgG CRIE中，治疗1年后对所有重要过敏原的放射染色增加，但在2年后，仅对磷脂酶（PLA）获得了持续或增加的放射染色。对于较弱的免疫原，可能更容易观察到放射染色的降低。
