Department of Medical Imaging, The Third Affiliated Hospital of Southern Medical University (Academy of Orthopedics·Guangdong Province), Guangzhou, China.
Department of Radiology, Affiliated Hospital of Guangdong Medical University, Guangdong Province,China.
Magn Reson Imaging. 2022 Dec;94:18-24. doi: 10.1016/j.mri.2022.07.014. Epub 2022 Jul 31.
To investigate the characteristics of fat content and component in IFP using hydrogen proton MR spectroscopy (H-MRS), and to explore the correlation with the severity of OA, Hoffa-synovitis, and knee pain.
80 volunteers were enrolled. Subjects were grouped based on Kellgren-Lawrence (K-L) grading. Fat fraction (FF) and unsaturation index (UI) of IFP were measured using H-MRS. Hoffa-synovitis was evaluated based on the MRI Osteoarthritis Knee Score system (MOAKS). Knee pain was assessed by a self-administered Western Ontario and McMaster Osteoarthritis Index (WOMAC) questionnaire. One-way ANOVA or Kruskal-Wallis test and Spearman's correlation tests were applied for statistical analysis.
After matching BMI, waistline, and K-L grade, a total of 64 knees were included and divided into 23 normal, 25 mild OA, and 16 advanced OA. The mean values were 76.79% ± 7.24%, 70.35% ± 7.42%, and 58.29% ± 10.32% for FF in the healthy controls, mild OA, and advanced OA group, and 6.36 ± 1.19%, 6.08 ± 1.35%, and 5.69 ± 1.78% for UI, respectively, the statistical difference was found for FF (p < 0.01). A good negative correlation was observed between the FF and the severity of OA, Hoffa-synovitis (r = -0.625, -0.758, respectively, p < 0.0001), and a weak inverse correlation with knee pain.
FF alteration in IFP is associated with the severity of OA, Hoffa synovitis, and knee pain, and has the potential to be a new quantitative imaging biomarker in knee OA.
利用氢质子磁共振波谱（H-MRS）研究 IFP 中的脂肪含量和成分特征，并探讨其与 OA 严重程度、Hoffa 滑膜炎症和膝关节疼痛的相关性。
共纳入 80 名志愿者。根据 Kellgren-Lawrence（K-L）分级对受试者进行分组。采用 H-MRS 测量 IFP 的脂肪分数（FF）和不饱和指数（UI）。根据 MRI 骨关节炎膝关节评分系统（MOAKS）评估 Hoffa 滑膜炎症。通过自填式 Western Ontario 和 McMaster 骨关节炎指数（WOMAC）问卷评估膝关节疼痛。采用单因素方差分析或 Kruskal-Wallis 检验和 Spearman 相关检验进行统计学分析。
在匹配 BMI、腰围和 K-L 分级后，共纳入 64 个膝关节，分为 23 个正常组、25 个轻度 OA 组和 16 个重度 OA 组。FF 的平均值分别为健康对照组、轻度 OA 组和重度 OA 组的 76.79%±7.24%、70.35%±7.42%和 58.29%±10.32%，UI 的平均值分别为 6.36±1.19%、6.08±1.35%和 5.69±1.78%，FF 的差异具有统计学意义（p<0.01）。FF 与 OA 严重程度、Hoffa 滑膜炎症（r=-0.625，-0.758，均 p<0.0001）呈良好的负相关，与膝关节疼痛呈弱负相关。
IFP 中的 FF 改变与 OA 严重程度、Hoffa 滑膜炎症和膝关节疼痛相关，有望成为膝骨关节炎的一种新的定量成像生物标志物。
