Center for Rehabilitation Medicine, Department of Radiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China.
Precision Health Institution, General Electric Healthcare, Hangzhou, China.
BMC Musculoskelet Disord. 2023 Apr 25;24(1):326. doi: 10.1186/s12891-023-06433-7.
The infrapatellar fat pad (IFP) may have bilateral influence on knee osteoarthritis (KOA). IFP evaluation may be a key contributor to the diagnostic and clinical management of KOA. Few studies have evaluated KOA-related IFP alteration with radiomics. We investigated radiomic signature for the assessment of IFP for KOA progression in older adults.
A total of 164 knees were enrolled and grouped based on Kellgren-Lawrence (KL) scoring. MRI-based radiomic features were calculated from IFP segmentation. The radiomic signature was developed using the most predictive subset of features and the machine-learning algorithm with minimum relative standard deviation. KOA severity and structure abnormality were assessed using a modified whole-organ magnetic resonance imaging score (WORMS). The performance of the radiomic signature was evaluated and the correlation with WORMS assessments was analyzed.
The area under the curve of the radiomic signature for diagnosing KOA was 0.83 and 0.78 in the training and test datasets, respectively. Rad-scores were 0.41 and 2.01 for the training dataset in the groups with and without KOA (P < 0.001) and 0.63 and 2.31 for the test dataset (P = 0.005), respectively. WORMS significantly and positively correlated with rad-scores.
The radiomic signature may be a reliable biomarker to detect IFP abnormality of KOA. Radiomic alterations in IFP were associated with severity and knee structural abnormalities of KOA in older adults.
髌下脂肪垫（IFP）可能对膝骨关节炎（KOA）有双侧影响。IFP 的评估可能是 KOA 诊断和临床管理的关键因素。很少有研究用放射组学评估与 KOA 相关的 IFP 改变。我们研究了放射组学特征，以评估老年人 KOA 进展中 IFP 的变化。
共纳入 164 个膝关节，根据 Kellgren-Lawrence（KL）评分进行分组。从 IFP 分割中计算基于 MRI 的放射组学特征。使用最具预测性的特征子集和最小相对标准偏差的机器学习算法开发放射组学特征。使用改良的全器官磁共振成像评分（WORMS）评估 KOA 严重程度和结构异常。评估放射组学特征的性能，并分析其与 WORMS 评估的相关性。
放射组学特征诊断 KOA 的曲线下面积在训练和测试数据集分别为 0.83 和 0.78。在有无 KOA 的组中，训练数据集的 rad-scores 分别为 0.41 和 2.01（P<0.001），测试数据集的 rad-scores 分别为 0.63 和 2.31（P=0.005）。WORMS 与 rad-scores 呈显著正相关。
放射组学特征可能是检测 KOA 中 IFP 异常的可靠生物标志物。IFP 的放射组学改变与老年人 KOA 的严重程度和膝关节结构异常相关。
