Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
J Microbiol Immunol Infect. 2022 Dec;55(6 Pt 1):1084-1093. doi: 10.1016/j.jmii.2022.07.003. Epub 2022 Jul 16.
The COVID-19 pandemic is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rapid identification and isolation of patients with COVID-19 are critical strategies to contain COVID-19. The saliva antigen test has the advantages of noninvasiveness and decreased transmission risk to health-care professionals. This meta-analysis investigated the diagnostic accuracy of the saliva antigen test for SARS-CoV-2.
We searched for relevant studies in PubMed, Embase, Cochrane Library, and Biomed Central. Studies evaluating the diagnostic accuracy of saliva antigen tests for SARS-CoV-2 were included. The data of the included studies were used to construct a 2 × 2 table on a per patient basis. The overall sensitivity and specificity of saliva antigen tests were determined using a bivariate random-effects model.
Nine studies enrolling 9842 patients were included. The meta-analysis generated a pooled sensitivity of 65.3% and a pooled specificity of 99.7%. A subgroup analysis of the studies performing the chemiluminescent enzyme immunoassay (CLEIA) for participants from airports and public health centers revealed a pooled sensitivity of 93.6%.
Our findings demonstrated that the saliva antigen test performed using CLEIA exhibited higher sensitivity for the detection of SARS-CoV-2. Therefore, the saliva antigen test performed using CLEIA might be an effective and noninvasive screening tool for SARS-CoV-2.
COVID-19 大流行是由严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2）引起的。快速识别和隔离 COVID-19 患者是遏制 COVID-19 的关键策略。唾液抗原检测具有非侵入性和降低对医护人员传播风险的优点。本荟萃分析调查了 SARS-CoV-2 唾液抗原检测的诊断准确性。
我们在 PubMed、Embase、Cochrane Library 和 Biomed Central 中搜索了相关研究。纳入评估 SARS-CoV-2 唾液抗原检测诊断准确性的研究。使用基于患者的 2×2 表对纳入研究的数据进行构建。使用双变量随机效应模型确定唾液抗原检测的总敏感性和特异性。
纳入了 9 项共 9842 名患者的研究。荟萃分析得出的唾液抗原检测的合并敏感性为 65.3%，特异性为 99.7%。对来自机场和公共卫生中心的参与者进行化学发光酶免疫分析（CLEIA）的研究进行亚组分析，发现合并敏感性为 93.6%。
我们的研究结果表明，使用 CLEIA 进行的唾液抗原检测对 SARS-CoV-2 的检测具有更高的敏感性。因此，使用 CLEIA 进行的唾液抗原检测可能是 SARS-CoV-2 的一种有效且非侵入性的筛查工具。
