Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Department of Pathology and Laboratory Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan.
Int J Environ Res Public Health. 2021 Oct 30;18(21):11451. doi: 10.3390/ijerph182111451.
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）引发了 2019 年冠状病毒病（COVID-19）的全球大流行。快速识别和隔离传染性患者是阻断 COVID-19 传播的关键方法。抗原检测有助于快速识别感染个体。本荟萃分析旨在评估 SARS-CoV-2 抗原检测的诊断准确性。我们在 PubMed、Embase、Cochrane 图书馆和 Biomed Central 数据库中进行了文献检索。纳入了评估社区参与者中 SARS-CoV-2 抗原检测诊断准确性的研究。仅对提供了可用于构建基于患者的 2×2 表的可用数据的合格研究进行了审查。使用双变量随机效应模型生成抗原检测的总体敏感性和特异性。检索到 18 项研究，涉及 34865 名参与者。对 SARS-CoV-2 抗原检测的荟萃分析得出，合并敏感性为 0.82，合并特异性为 1.00。对 10 项报告了 5629 例有症状参与者结局的研究进行的亚组分析得出，合并敏感性为 0.87，合并特异性为 1.00。抗原检测在检测社区中有症状患者的 SARS-CoV-2 时可能具有更高的敏感性，并且可能是识别需要隔离以防止 SARS-CoV-2 进一步传播的患者的有效工具。
