Blood Transfusion Department, Anhui No. 2 Provincial People's Hospital, Hefei, Anhui, China.
Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui, China.
J Med Virol. 2022 Dec;94(12):6016-6022. doi: 10.1002/jmv.28045. Epub 2022 Aug 17.
The seroprevalence of Kaposi's sarcoma-associated herpesvirus (KSHV) is high in Xinjiang, China. But the seroprevalence of KSHV and risk factors are still unknown in Gansu which is adjacent to Xinjiang. Six hundred and seventy-eight serum samples of the general population and 87 serum samples of syphilis patients from Jiuquan, Gansu were tested for antibodies against KSHV, including one latent protein (ORF73) and two lytic proteins (ORF65 and K8.1) using the ELISA. The total KSHV-seropositive rate was 15.9% in 678 serum samples in the Jiuquan area, and the KSHV-seropositive rate of males was higher than females (18.0% vs. 14.6%, p > 0.05). The Uygur, Kazakh, Hui, Manchu, and Mongolian populations had a higher seroprevalence of KSHV than the Han population (43.8%, 40.0%, 34.5%, 30.3%, 35.0% vs. 11.0%, respectively) among the ethnic groups in Jiuquan. Compared to the Han, Uygur, Kazak, Hui, Manchu, and Mongolian people had an increase in the risk of KSHV of 528.9%, 439.1%, 325.6%, 251.6%, and 335.4% (p < 0.001, p < 0.001, p < 0.001, p = 0.002, p = 0.003, respectively). The serum prevalence of KSHV in subjects aged < 20 years, 20-50 years, and >50 years was 13.8%, 14.7%, and 20.1%, respectively. Compared to the subjects aged < 20 years, 20-50 years and >50 years had an increase in the risk of KSHV of 7.4% and 56.9% (p = 0.829 and p = 0.204, respectively). Compared to the positive rate of KSHV in the general population of Anhui, the positive rate of KSHV was significantly higher in the general population of the Jiuquan area (15.9% vs. 9%, p < 0.01). There was no significant difference in the positive rate of KSHV between the Han population of Jiuquan and the Han population of Anhui (p > 0.05). In the population of syphilis patients in the Jiuquan area, the positive rate of KSHV was 30.7%, which was higher than that of the general population in the Gansu area (p < 0.05). This study indicates that Gansu has a high seroprevalence of KSHV. Ethnicity and syphilis are risk factors for KSHV infection.
中国新疆的卡波西肉瘤相关疱疹病毒（KSHV）血清流行率较高。然而，与新疆接壤的甘肃的 KSHV 血清流行率和危险因素仍不清楚。本研究采用酶联免疫吸附试验（ELISA）检测了来自甘肃酒泉的 678 份普通人群血清样本和 87 份梅毒患者血清样本中针对 KSHV 的抗体，包括一种潜伏蛋白（ORF73）和两种裂解蛋白（ORF65 和 K8.1）。在酒泉地区的 678 份血清样本中，总 KSHV 血清阳性率为 15.9%，男性的 KSHV 血清阳性率高于女性（18.0%比 14.6%，p>0.05）。与汉族相比，酒泉地区的维吾尔族、哈萨克族、回族、满族和蒙古族人群的 KSHV 血清阳性率更高（43.8%、40.0%、34.5%、30.3%和 35.0%，分别）。与汉族相比，维吾尔族、哈萨克族、回族、满族和蒙古族人群感染 KSHV 的风险分别增加了 528.9%、439.1%、325.6%、251.6%和 335.4%（p<0.001、p<0.001、p<0.001、p=0.002、p=0.003，分别）。年龄<20 岁、20-50 岁和>50 岁的 KSHV 血清流行率分别为 13.8%、14.7%和 20.1%。与年龄<20 岁的人群相比，20-50 岁和>50 岁人群感染 KSHV 的风险分别增加了 7.4%和 56.9%（p=0.829 和 p=0.204，分别）。与安徽普通人群的 KSHV 阳性率相比，酒泉普通人群的 KSHV 阳性率明显更高（15.9%比 9%，p<0.01）。酒泉汉族人群与安徽汉族人群的 KSHV 阳性率无统计学差异（p>0.05）。在酒泉梅毒患者人群中，KSHV 的阳性率为 30.7%，高于甘肃地区的普通人群（p<0.05）。本研究表明，甘肃的 KSHV 血清流行率较高。种族和梅毒是 KSHV 感染的危险因素。
