Wen Zhi, Li Wenli, Fang Yuan, Zhou Chang, Lin Kang, Wu Huanwu, Zhang Yiting, Zhu Yulin, Xu Xingchen, Zeng Yan, Lu Baojing, Wang Linding
Department of Microbiology and Parasitology, The Key Laboratory of Microbiology and Parasitology of Anhui Province, The Key Laboratory of Zoonoses of High Institutions in Anhui, School of Basic Medical Sciences, Anhui Medical University, Hefei 230032, Anhui, China.
The People's Hospital of Xuancheng City, Xuancheng 242000, Anhui, China.
Can J Infect Dis Med Microbiol. 2021 Dec 31;2021:2555865. doi: 10.1155/2021/2555865. eCollection 2021.
Kaposi's sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi's sarcoma (KS), which is endangering human health worldwide, especially in Africa, Europe, the United States, and parts of Asia. The aim of this study was to investigate the prevalence of KSHV in Xinjiang. Three KSHV recombinant proteins (ORF65, ORF73, and K8.1) were used to detect KSHV infection. The serum samples to be tested were detected by an indirect ELISA method. The overall infection rate of KSHV in Xinjiang was 25.60%, with a higher infection rate in the Uygur population of 29.79%. After adjusting for possible confounders, Uygur (OR = 3.95, 95% CI 2.64-6.12, < 0.001), agriculture and livestock (OR = 1.60, 95% CI 1.20-2.17, = 0.002), age ≤ 50 years (OR = 1.50, 95% CI 1.13-2.00, = 0.006), and predominantly meat-based diet (OR = 1.72, 95% CI 1.11-2.78, = 0.018) were significantly associated with the odds of KSHV seropositivity correlation. Three unique sequences of KSHV were obtained in this study; genotypic analysis showed that the three unique sequences were all subtype A2.
卡波西肉瘤相关疱疹病毒（KSHV）是卡波西肉瘤（KS）的病原体，KS在全球范围内危害人类健康，尤其是在非洲、欧洲、美国和亚洲部分地区。本研究旨在调查新疆KSHV的流行情况。使用三种KSHV重组蛋白（ORF65、ORF73和K8.1）检测KSHV感染。采用间接ELISA法检测待检测的血清样本。新疆KSHV的总体感染率为25.60%，维吾尔族人群的感染率较高，为29.79%。在对可能的混杂因素进行调整后，维吾尔族（OR = 3.95，95%CI 2.64 - 6.12，P < 0.001）、农牧业（OR = 1.60，95%CI 1.20 - 2.17，P = 0.002）、年龄≤50岁（OR = 1.50，95%CI 1.13 - 2.00，P = 0.006）以及以肉类为主的饮食（OR = 1.72，95%CI 1.11 - 2.78，P = 0.018）与KSHV血清阳性相关性的几率显著相关。本研究获得了KSHV的三个独特序列；基因型分析表明，这三个独特序列均为A2亚型。
