在夏威夷发现 HIV-1 CRF01_AE 亚型及其影响
Identification and Implications of HIV-1 CRF01_AE Subtype in Hawai'i.
机构信息
John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI (LSD, INS, CMS).
Weil Cornell Medicine, New York, NY (INS).
出版信息
Hawaii J Health Soc Welf. 2022 Aug;81(8):215-217.
Human Immunodeficiency Virus has a high propensity for genetic variation, demonstrated by its complex phylogeny and multiplicity of subtypes. Subtype B is predominant in North America as well as in Hawai'i while CRF01_AE is found in over 50% of cases in the Philippines and Southeast Asia. In a small collaborative study between the Hawai'i Center for AIDS and Philippines General Hospital, molecular phylogenetic subtyping was conducted on HIV+ participants. Two of 15 (13%) participants from the Hawai'i cohort and 12 of 21 (57%) participants from the Philippines cohort were identified as having CRF01_AE subtype of HIV-1, with remaining participants identified as subtype B. While one individual in Hawai'i with CRF01_AE had emigrated from the Philippines, the other participant from Hawai'i with CRF01_AE subtype was a local individual, born and raised in Hawai'i. The authors report that HIV subtype diversity may be increased in Hawai'i and discuss its potential clinical and public health implications.
人类免疫缺陷病毒（HIV）具有高度的遗传变异倾向，其复杂的系统发育和多种亚型都证明了这一点。B 亚型在北美洲和夏威夷也很常见，而 CRF01_AE 在菲律宾和东南亚超过 50%的病例中都有发现。在夏威夷艾滋病中心和菲律宾总医院之间的一项小型合作研究中，对 HIV+参与者进行了分子系统发育亚型分析。在来自夏威夷队列的 15 名参与者中，有 2 名（13%）和来自菲律宾队列的 21 名参与者中的 12 名（57%）被确定为 HIV-1 的 CRF01_AE 亚型，其余参与者被确定为 B 亚型。虽然夏威夷的一名 CRF01_AE 感染者是从菲律宾移民来的，但另一名来自夏威夷的 CRF01_AE 感染者是土生土长的夏威夷人。作者报告说，HIV 亚型的多样性可能在夏威夷有所增加，并讨论了其潜在的临床和公共卫生影响。
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