Robertson Jamie M, Basany Kalpana, Farooq Fouzia, Tan Xiaoqing, Tang Gong, Bunker Clareann H, Reddy P S, Haggerty Catherine L
Department of Epidemiology, University of Pittsburgh, 130 Desoto Street, Pittsburgh, PA 15261 USA.
Department of Surgery, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115 USA.
J Obstet Gynaecol India. 2022 Aug;72(4):314-321. doi: 10.1007/s13224-021-01498-7. Epub 2021 Jul 28.
Consanguineous marriage (CM) has been linked to spontaneous abortion (SAB), although studies have largely been cross-sectional and likely underestimated early loss. We aimed to determine the relationships between CM and SAB in a prospective pregnancy cohort study in Telangana State, India.
Data from 661 participants aged 15-35 years in the Longitudinal Indian Family hEalth (LIFE) study actively followed for pregnancy and pregnancy loss were analyzed. SAB was classified as early (< 8) or late (8-22) weeks gestation. We used logistic regression to model the relationships between CM, defined by first-cousin marriage, and SAB, adjusted for maternal age.
Women in CM were at a modestly increased risk of any (OR 1.15, 95% CI 0.69, 1.91) and early (OR 2.03, 95% CI 0.85, 4.83) SAB compared to women in non-CM, although results were not statistically significant. There was no relationship between CM and late SAB.
Among couples in southern India, there was a modest increase in early but not late SAB among CMs which may be explained by the expected influence of chromosomal abnormalities and lethal homozygous recessive disease on early loss. Pre- and Peri-marital Health Counseling that addresses this risk may be warranted.
The online version contains supplementary material available at 10.1007/s13224-021-01498-7.
近亲结婚（CM）与自然流产（SAB）有关，尽管此前的研究大多为横断面研究，可能低估了早期流产情况。我们旨在通过印度特伦甘纳邦的一项前瞻性妊娠队列研究，确定近亲结婚与自然流产之间的关系。
对印度纵向家庭健康（LIFE）研究中661名年龄在15 - 35岁、积极随访妊娠及流产情况的参与者的数据进行分析。自然流产分为妊娠早期（<8周）或晚期（8 - 22周）。我们使用逻辑回归模型来分析由表亲结婚定义的近亲结婚与自然流产之间的关系，并对母亲年龄进行了校正。
与非近亲结婚的女性相比，近亲结婚的女性发生任何自然流产（比值比[OR] 1.15，95%置信区间[CI] 0.69，1.91）和早期自然流产（OR 2.03，95% CI 0.85，4.83）的风险略有增加，尽管结果无统计学意义。近亲结婚与晚期自然流产之间没有关系。
在印度南部的夫妇中，近亲结婚的女性早期自然流产风险略有增加，但晚期自然流产风险未增加，这可能是由于染色体异常和致死性纯合隐性疾病对早期流产的预期影响所致。针对这种风险的婚前和孕期健康咨询可能是必要的。
在线版本包含可在10.1007/s13224 - 021 - 01498 - 7获取的补充材料。
