Kasahun Asmamaw Emagn, Sendekie Ashenafi Kibret, Mekonnen Gizework Alemnew, Sema Faisel Dula, Kemal Leila Kenzu, Abebe Rahel Belete
Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Department of Clinical Pharmacy, School of Pharmacy, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
Patient Prefer Adherence. 2022 Jul 27;16:1787-1803. doi: 10.2147/PPA.S370178. eCollection 2022.
Subjective beliefs about chronic disease conditions and their drug management are among factors determining adherence to medications that are amenable to interventions. Patient-level factors such as personal, cultural, and religious beliefs about diseases, and medication use may have a significant impact on medication adherence. The purpose of this study was to assess the impact of personal, cultural and religious beliefs on medication adherence behavior among patients with chronic follow-up.
An institutional-based cross-sectional study design was conducted among chronic ambulatory patients from July to August 2021. The data was collected through an interviewer administered questionnaire. Initially stratified sampling technique was used to include proportional participants from different disease conditions, and systematic random sampling was employed to enroll eligible patients from each subgroup. Descriptive statistics such as frequencies and percentages were computed for categorical variables and mean with (standard deviation ±SD) used for continuous variables. Logistic regression model was employed to determine variable with poor adherence. A 95% confidence interval with P-value ≤0.05 was used to declare statically significance.
Among the 404 participants, more than half (51%) were males. The mean (±SD) age of the patients was 47.8 ± 14.8 years. Patients with strong belief in the harm of medications were found 4 times more likely to have poor medication adherence than those with weak belief in the harm of medications (AOR = 4.027, 95% CI:1.232-13.161, P = 0.021). In contrast, having strong personal belief regarding the necessity of medications were found to be less likely to have poor medication adherence (AOR = 0.368, 95% CI: 0.220-0.615, P < 0.001).
This study generalized that most of the patients were poor adherent to their medications. Personal beliefs were found to influence medication adherence of the patients. Future studies could be needed to explore and identify how these factors affect patients' medication adherence.
关于慢性病状况及其药物治疗的主观信念是决定对适合干预的药物治疗依从性的因素之一。患者层面的因素，如个人、文化和宗教对疾病及用药的信念，可能对药物治疗依从性产生重大影响。本研究的目的是评估个人、文化和宗教信念对长期随访患者药物治疗依从性行为的影响。
2021年7月至8月，对慢性病门诊患者进行了一项基于机构的横断面研究设计。数据通过访员管理的问卷收集。最初采用分层抽样技术纳入来自不同疾病状况的比例参与者，然后采用系统随机抽样从每个亚组中招募符合条件的患者。分类变量计算频率和百分比等描述性统计量，连续变量计算均值（标准差±SD）。采用逻辑回归模型确定依从性差的变量。使用95%置信区间且P值≤0.05来判定具有统计学意义。
在404名参与者中，超过一半（51%）为男性。患者的平均（±SD）年龄为47.8±14.8岁。发现对药物危害坚信的患者药物治疗依从性差的可能性是对药物危害信念较弱患者的4倍（比值比=4.027，95%置信区间：1.232 - 13.161，P = 0.021）。相比之下，对药物必要性有强烈个人信念的患者药物治疗依从性差的可能性较小（比值比=0.368，95%置信区间：0.220 - 0.615，P < 0.001）。
本研究推断大多数患者对药物治疗的依从性较差。发现个人信念会影响患者的药物治疗依从性。未来可能需要进一步研究来探索和确定这些因素如何影响患者的药物治疗依从性。
