Myers L L, Shoop D S
Am J Vet Res. 1987 May;48(5):774-5.
Enterotoxigenic Bacteroides fragilis (ETBF) was isolated from intestinal contents of 10 of 45 pigs with diarrhea. Of 10 ETBF-positive pigs, seven were 1 to 4 weeks of age, whereas three pigs had diarrhea after weaning (6 to 8 weeks of age). Of ten pigs infected with ETBF, nine were also infected with K88-positive Escherichia coli, rotavirus, coronavirus, coccidia, or Cryptosporidium. Of 11 conventional pigs exposed to ETBF at 1 to 2 days of age, two subsequently developed fatal postweaning diarrhea. An ETBF isolate, serologically similar to the challenge-exposure strain, was isolated from the feces of the two diarrheal pigs, but not from three healthy littermates. Fatal enteric disease occurred in 11 of 12 adult rabbits with ligated ceca after approximately 5 X 10(9) colony-forming units of ETBF were injected into the ileum. Disease in rabbits was characterized by anorexia and severe, mucoid, hemorrhagic diarrhea. Of 11 rabbits given non-ETBF or sterile brain-heart infusion broth, ten remained clinically normal during the 7-day observation period.
从45头腹泻猪的肠道内容物中分离出了产肠毒素脆弱拟杆菌（ETBF）。在10头ETBF阳性猪中，7头为1至4周龄，而3头猪在断奶后（6至8周龄）出现腹泻。在10头感染ETBF的猪中，9头还感染了K88阳性大肠杆菌、轮状病毒、冠状病毒、球虫或隐孢子虫。11头在1至2日龄时接触ETBF的普通猪中，有2头随后出现致命的断奶后腹泻。从这2头腹泻猪的粪便中分离出了一株血清学上与攻击暴露菌株相似的ETBF分离株，但在3头健康同窝仔猪的粪便中未分离到。在将约5×10⁹个ETBF菌落形成单位注入回肠后，12只成年结扎盲肠的兔子中有11只发生了致命的肠道疾病。兔子的疾病表现为厌食和严重的、黏液性、出血性腹泻。在11只给予非ETBF或无菌脑心浸液肉汤的兔子中，10只在7天观察期内临床正常。
