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比较分析不同驯化和野生猪种的粪便微生物群。

Comparative analysis of the fecal microbiota from different species of domesticated and wild suids.

机构信息

IRTA, Centre de Recerca en Sanitat Animal (CReSA, IRTA-UAB), Campus de la Universitat Autònoma de Barcelona, 08193, Bellaterra, Spain.

International Livestock Research Institute (ILRI), P.O. Box 30709, 00100, Nairobi, Kenya.

出版信息

Sci Rep. 2019 Sep 20;9(1):13616. doi: 10.1038/s41598-019-49897-1.

DOI:10.1038/s41598-019-49897-1
PMID:31541124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6754420/
Abstract

Most of the microorganisms living in a symbiotic relationship in different animal body sites (microbiota) reside in the gastrointestinal tract (GIT). Several studies have shown that the microbiota is involved in host susceptibilities to pathogens. The fecal microbiota of domestic and wild suids was analyzed. Bacterial communities were determined from feces obtained from domestic pigs (Sus scrofa) raised under different conditions: specific-pathogen-free (SPF) pigs and domestic pigs from the same bred, and indigenous domestic pigs from a backyard farm in Kenya. Secondly, the fecal microbiota composition of the African swine fever (ASF) resistant warthogs (Phacochoerus africanus) from Africa and a European zoo was determined. African swine fever (ASF) is a devastating disease for domestic pigs. African animals showed the highest microbial diversity while the SPF pigs the lowest. Analysis of the core microbiota from warthogs (resistant to ASF) and pigs (susceptible to ASF) showed 45 shared OTUs, while 6 OTUs were exclusively present in resistant animals. These six OTUs were members of the Moraxellaceae family, Pseudomonadales order and Paludibacter, Anaeroplasma, Petrimonas, and Moraxella genera. Further characterization of these microbial communities should be performed to determine the potential involvement in ASF resistance.

摘要

大多数生活在不同动物体部位（微生物群）共生关系中的微生物都存在于胃肠道（GIT）中。多项研究表明，微生物群参与宿主对病原体的易感性。分析了家养和野生猪的粪便微生物群。从不同条件下饲养的家猪（Sus scrofa）的粪便中确定了细菌群落：无特定病原体（SPF）猪和来自同一品种的家猪，以及肯尼亚后院农场的本地家猪。其次，还确定了来自非洲和一个欧洲动物园的抗非洲猪瘟（ASF）疣猪（Phacochoerus africanus）的粪便微生物群组成。非洲猪瘟（ASF）是家猪的毁灭性疾病。非洲动物表现出最高的微生物多样性，而 SPF 猪则表现出最低的多样性。对抗 ASF 的疣猪（对 ASF 有抵抗力）和易感 ASF 的猪的核心微生物群进行分析显示，有 45 个共有 OTUs，而 6 个 OTUs仅存在于抗性动物中。这 6 个 OTU 是莫拉氏菌科、假单胞菌目和 Paludibacter、Anaeroplasma、Petrimonas 和 Moraxella 属的成员。应进一步对这些微生物群落进行表征，以确定其在 ASF 抗性中的潜在作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/7f9f17b3728e/41598_2019_49897_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/e9ab1669eecb/41598_2019_49897_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/00a805afaaa1/41598_2019_49897_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/260db367f705/41598_2019_49897_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/7f9f17b3728e/41598_2019_49897_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/e9ab1669eecb/41598_2019_49897_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/50625940f749/41598_2019_49897_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/8cd876bb47db/41598_2019_49897_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/0dea3da1e21b/41598_2019_49897_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/00a805afaaa1/41598_2019_49897_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/260db367f705/41598_2019_49897_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dc99/6754420/7f9f17b3728e/41598_2019_49897_Fig7_HTML.jpg

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